PMID- 9389449
OWN - NLM
STAT- MEDLINE
DCOM- 19980210
LR  - 20090929
IS  - 1058-8388 (Print)
IS  - 1058-8388 (Linking)
VI  - 210
IP  - 3
DP  - 1997 Nov
TI  - Differential expression of the rat retinoid X receptor gamma gene during skeletal 
      muscle differentiation suggests a role in myogenesis.
PG  - 227-35
AB  - Even though previous studies have shown that transcripts encoding the murine 
      retinoid X receptor gamma (RXRgamma) are present in skeletal muscle of mouse 
      embryos and that cultured myoblasts are induced to differentiate upon retinoid 
      treatment, a function for RXRgamma and retinoids in mammalian myogenesis has not 
      yet been identified. To begin to understand the possible role of RXRgamma during 
      mammalian myogenesis we isolated novel rat RXRgamma cDNA sequences and examined 
      in detail the spatio-temporal expression pattern of RXRgamma transcripts in 
      relation to skeletal muscle differentiation in rat embryos and cultured 
      myoblasts. We show that the onset of RXRgamma expression coincides with the 
      differentiation of limb myoblasts in vivo. In vitro, RXRgamma is expressed in 
      differentiating myoblasts, but not in proliferating myoblasts. In the myotome, 
      however, RXRgamma is first expressed after myoblast differentiation, with 
      RXRgamma transcripts being confined initially to its ventral region. 
      Subsequently, RXRgamma becomes expressed throughout limb and myotome-derived 
      muscle masses, and by the end of the primary myogenic wave, RXRgamma transcripts 
      are mainly confined to their periphery. This dynamic expression pattern of 
      RXRgamma during myogenesis suggests its possible involvement in the 
      differentiation of limb myoblasts but excludes a role in the differentiation of 
      early myotomal myoblasts.
FAU - Georgiades, P
AU  - Georgiades P
AD  - Department of Molecular Pathology, University College London Medical School, 
      England.
FAU - Brickell, P M
AU  - Brickell PM
LA  - eng
SI  - GENBANK/AF016387
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Dyn
JT  - Developmental dynamics : an official publication of the American Association of 
      Anatomists
JID - 9201927
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - DNA, Complementary/chemistry
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Expression Regulation
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/cytology/*embryology
MH  - Nuclear Proteins/*genetics
MH  - Rats
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoid X Receptors
MH  - Transcription Factors/*genetics
EDAT- 1997/12/06 11:03
MHDA- 2000/06/22 10:00
CRDT- 1997/12/06 11:03
PHST- 1997/12/06 11:03 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1997/12/06 11:03 [entrez]
AID - 10.1002/(SICI)1097-0177(199711)210:3<227::AID-AJA4>3.0.CO;2-I [pii]
AID - 10.1002/(SICI)1097-0177(199711)210:3<227::AID-AJA4>3.0.CO;2-I [doi]
PST - ppublish
SO  - Dev Dyn. 1997 Nov;210(3):227-35. doi: 
      10.1002/(SICI)1097-0177(199711)210:3<227::AID-AJA4>3.0.CO;2-I.