PMID- 9389504
OWN - NLM
STAT- MEDLINE
DCOM- 19971229
LR  - 20081121
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 138
IP  - 12
DP  - 1997 Dec
TI  - Interferon-gamma potentiates interleukin (IL)-6 and tumor necrosis factor-alpha 
      but not IL-1beta induced by endotoxin in the brain.
PG  - 5220-6
AB  - Because interferon-gamma (IFN gamma) is present in the central nervous system 
      during neurologic diseases associated with inflammation, its effect on 
      endotoxin-induced cytokines was studied. Cerebrospinal fluid (CSF) and serum 
      levels of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF 
      alpha), their messenger RNA expression in brain areas (hypothalamus, hippocampus, 
      and striatum) and in spleen were evaluated 2 and 8 h after endotoxin 
      [lipopolysaccharide (LPS), 25 microg/rat i.c.v.], IFN gamma (2.5 microg/rat 
      i.c.v.) or after their coadministration in rats. CSF and serum IL-1beta levels 
      were increased by LPS alone and IFN gamma coadministration did not furtherly 
      increase them. IFN gamma potentiated LPS effect on IL-6 and TNF alpha levels in 
      both CSF and serum. LPS and IFN-gamma coadministration did not alter IL-1beta 
      messenger RNA expression induced by LPS in brain areas and in spleen, but it 
      potentiated that of IL-6 and TNF alpha. The present in vivo data show that i.c.v. 
      coadministration of LPS and IFN gamma results in a potentiation of cytokine 
      production (IL-6 and TNF alpha) which may trigger a cascade of events relevant to 
      neurodegenerative processes. This action is independent of IL-1beta because the 
      production of this cytokine is not altered by IFN gamma treatment.
FAU - De Simoni, M G
AU  - De Simoni MG
AD  - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. 
      de-simoni@irfmn.mnegri.it
FAU - Terreni, L
AU  - Terreni L
FAU - Chiesa, R
AU  - Chiesa R
FAU - Mangiarotti, F
AU  - Mangiarotti F
FAU - Forloni, G L
AU  - Forloni GL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Cytokines/blood/cerebrospinal fluid
MH  - Interferon-gamma/*pharmacology
MH  - Interleukin-1/genetics/*metabolism
MH  - Interleukin-6/genetics/*metabolism
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
EDAT- 1997/12/06 00:00
MHDA- 1997/12/06 00:01
CRDT- 1997/12/06 00:00
PHST- 1997/12/06 00:00 [pubmed]
PHST- 1997/12/06 00:01 [medline]
PHST- 1997/12/06 00:00 [entrez]
AID - 10.1210/endo.138.12.5616 [doi]
PST - ppublish
SO  - Endocrinology. 1997 Dec;138(12):5220-6. doi: 10.1210/endo.138.12.5616.