PMID- 9389705
OWN - NLM
STAT- MEDLINE
DCOM- 19971229
LR  - 20231213
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 90
IP  - 12
DP  - 1997 Dec 15
TI  - Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 
      in hematologic malignancies identified by fluorescence in situ hybridization: TEL 
      (ETV6 ) is involved in only one half.
PG  - 4886-93
AB  - Using fluorescence in situ hybridization (FISH) and probes located on 12p12.1 to 
      13.3, we studied the breakpoints of 23 patients who had various hematologic 
      malignant diseases and who had 12p13-balanced translocations (21 patients), 
      inversion (1 patient), or insertion (1 patient). Among them, 14 patients had 
      breakpoints within YAC964c10, which contains the TEL (ETV6 ) gene and in 12 of 
      these with balanced translocations or insertion, the FISH results suggested that 
      TEL was involved. Two of the 14 patients, patients no. 13 and 14, had breakpoints 
      in YAC 964C10 that were centromeric to TEL but telomeric to KIP1. In the other 9 
      patients whose breakpoints did not fall within the YAC, the breakpoints were 
      found telomeric to the YAC in at least three different locations on distal 12p. 
      These results indicated that TEL was involved in only half (12 of 23) of the 
      patients with balanced 12p13 rearrangements and that there probably were several 
      other breakpoint cluster regions on 12p13, suggesting that genes other than TEL 
      were involved in these rearrangements.
FAU - Sato, Y
AU  - Sato Y
AD  - University of Chicago, Department of Medicine, Section of Hematology/Oncology, 
      Chicago, IL 60637-1470, USA.
FAU - Bohlander, S K
AU  - Bohlander SK
FAU - Kobayashi, H
AU  - Kobayashi H
FAU - Reshmi, S
AU  - Reshmi S
FAU - Suto, Y
AU  - Suto Y
FAU - Davis, E M
AU  - Davis EM
FAU - Espinosa, R
AU  - Espinosa R
FAU - Hoopes, R
AU  - Hoopes R
FAU - Montgomery, K T
AU  - Montgomery KT
FAU - Kucherlapati, R S
AU  - Kucherlapati RS
FAU - Le Beau, M M
AU  - Le Beau MM
FAU - Rowley, J D
AU  - Rowley JD
LA  - eng
GR  - CA40046/CA/NCI NIH HHS/United States
GR  - CA42557/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Inversion
MH  - *Chromosomes, Human, Pair 12
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - *Gene Rearrangement
MH  - Hematologic Neoplasms/*genetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-ets
MH  - *Repressor Proteins
MH  - Transcription Factors/*genetics
MH  - *Translocation, Genetic
MH  - ETS Translocation Variant 6 Protein
EDAT- 1998/01/07 00:00
MHDA- 1998/01/07 00:01
CRDT- 1998/01/07 00:00
PHST- 1998/01/07 00:00 [pubmed]
PHST- 1998/01/07 00:01 [medline]
PHST- 1998/01/07 00:00 [entrez]
AID - S0006-4971(20)54952-5 [pii]
PST - ppublish
SO  - Blood. 1997 Dec 15;90(12):4886-93.