PMID- 9390638
OWN - NLM
STAT- MEDLINE
DCOM- 19971218
LR  - 20191102
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 130
IP  - 5
DP  - 1997 Nov
TI  - Evaluation of the hepatic iron index as a diagnostic criterion for genetic 
      hemochromatosis.
PG  - 509-14
AB  - The hepatic iron index was originally described as a useful test to discriminate 
      genetic hemochromatosis from alcoholic siderosis. To evaluate the hepatic iron 
      index as a diagnostic criterion, it is essential to evaluate a cohort of 
      hemochromatosis patients in whom the diagnosis has been established with great 
      certainty. The presence of a sibling with identical human leukocyte antigen (HLA) 
      and with iron overload was considered to be the gold standard for the diagnosis. 
      Hepatic iron index was reviewed retrospectively in 55 homozygotes and in 189 
      patients who did not have hemochromatosis and were referred for hepatic iron 
      analysis. Four of 55 homozygotes (7%) had a hepatic iron index of < or = 1.9. 
      Hepatic iron concentration was increased in all 4 patients, ranging from 36 to 
      100 micromol/gm dry weight, (normal value <35.5 micromol/gm). Twelve of 189 (6%) 
      patients without hemochromatosis had hepatic iron indexes > 1.9. The positive 
      likelihood ratio for a hepatic iron index of 1.9 was 12.4. Area under the 
      receiver operating characteristic curve was 0.94 (0.9 to 0.99, 95% confidence 
      interval). The hepatic iron index remains a useful tool in the diagnosis of 
      genetic hemochromatosis. However, it should not be an absolute criterion for the 
      diagnosis and should be interpreted in combination with clinical assessment and 
      genetic studies.
FAU - Adams, P C
AU  - Adams PC
AD  - Department of Medicine, London Health Sciences Centre, University of Western 
      Ontario, Canada.
FAU - Bradley, C
AU  - Bradley C
FAU - Henderson, A R
AU  - Henderson AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - 0 (HLA Antigens)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - HLA Antigens/genetics
MH  - Hemochromatosis/*diagnosis/*genetics
MH  - Homozygote
MH  - Humans
MH  - Iron/*analysis
MH  - Iron Overload/metabolism
MH  - Liver/*chemistry
MH  - Male
MH  - Middle Aged
MH  - Nuclear Family
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
EDAT- 1997/12/09 00:00
MHDA- 1997/12/09 00:01
CRDT- 1997/12/09 00:00
PHST- 1997/12/09 00:00 [pubmed]
PHST- 1997/12/09 00:01 [medline]
PHST- 1997/12/09 00:00 [entrez]
AID - S0022-2143(97)90127-X [pii]
AID - 10.1016/s0022-2143(97)90127-x [doi]
PST - ppublish
SO  - J Lab Clin Med. 1997 Nov;130(5):509-14. doi: 10.1016/s0022-2143(97)90127-x.