PMID- 9392586
OWN - NLM
STAT- MEDLINE
DCOM- 19971217
LR  - 20190516
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 57
IP  - 5
DP  - 1997 Nov
TI  - Involvement of cytokines in the histopathology of cerebral malaria.
PG  - 501-6
AB  - Histopathologic and immunohistologic studies were performed in two cases of fatal 
      cerebral malaria. On admission, both patients were in unarousable coma with 
      hyperparasitemia. Examination of the tissue sections from various organs showed 
      parasite sequestration in both cases with more extensive area of sequestration in 
      case 1 than in case 2. A panel of monoclonal antibodies against cytokines applied 
      to these tissues clearly detected tumor necrosis factor-alpha (TNF alpha), 
      interferon-gamma (IFN gamma), interleukin-1beta (IL-1beta), and IL-10 in the 
      tissues from brain and liver of case 1. A different cytokine profile, IL-4 and 
      IL-10, was found in the brain tissues of case 2; no TNF alpha nor IFN gamma was 
      detected. There was no cytokine detected in the tissues of other organs in either 
      case. Results of the study suggest that histopathology in the brain of fatal 
      cerebral malaria may be associated with focal accumulation of cytokines. 
      Additionally, the type of cytokines produced locally in a particular tissue 
      during malaria infection may be regulated by the degree of regional parasite 
      sequestration.
FAU - Udomsangpetch, R
AU  - Udomsangpetch R
AD  - Department of Pathobiology, Faculty of Science, and Hospital for Tropical 
      Diseases, Mahidol University, Bangkok, Thailand.
FAU - Chivapat, S
AU  - Chivapat S
FAU - Viriyavejakul, P
AU  - Viriyavejakul P
FAU - Riganti, M
AU  - Riganti M
FAU - Wilairatana, P
AU  - Wilairatana P
FAU - Pongponratin, E
AU  - Pongponratin E
FAU - Looareesuwan, S
AU  - Looareesuwan S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cytokines/analysis/*physiology
MH  - Humans
MH  - Interferon-gamma/analysis/physiology
MH  - Malaria, Cerebral/*pathology
MH  - Male
MH  - Tumor Necrosis Factor-alpha/analysis/physiology
EDAT- 1997/12/10 00:00
MHDA- 1997/12/10 00:01
CRDT- 1997/12/10 00:00
PHST- 1997/12/10 00:00 [pubmed]
PHST- 1997/12/10 00:01 [medline]
PHST- 1997/12/10 00:00 [entrez]
AID - 10.4269/ajtmh.1997.57.501 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 1997 Nov;57(5):501-6. doi: 10.4269/ajtmh.1997.57.501.