PMID- 9396611
OWN - NLM
STAT- MEDLINE
DCOM- 19980109
LR  - 20190914
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 3
IP  - 12
DP  - 1997 Dec
TI  - Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased 
      IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA.
PG  - 1394-7
AB  - Viruses have long been suggested to be involved in the etiology of multiple 
      sclerosis (MS). This suggestion is based on (1) epidemiological evidence of 
      childhood exposure to infectious agents and increase in disease exacerbations 
      with viral infection; (2) geographic association of disease susceptibility with 
      evidence of MS clustering; (3) evidence that migration to and from high-risk 
      areas influences the likelihood of developing MS; (4) abnormal immune responses 
      to a variety of viruses; and (5) analogy with animal models and other human 
      diseases in which viruses can cause diseases with long incubation periods, a 
      relapsing-remitting course, and demyelination. Many of these studies involve the 
      demonstration of increased antibody titers to a particular virus, whereas some 
      describe isolation of virus from MS material. However, no virus to date has been 
      definitively associated with this disease. Recently, human herpesvirus 6 (HHV-6), 
      a newly described beta-herpes virus that shares homology with cytomegalovirus 
      (CMV), has been reported to be present in active MS plaques. In order to extend 
      these observations, we have demonstrated increased IgM serum antibody responses 
      to HHV-6 early antigen (p41/38) in patients with relapsing-remitting MS (RRMS), 
      compared with patients with chronic progressive MS (CPMS), patients with other 
      neurologic disease (OND), patients with other autoimmune disease (OID), and 
      normal controls. Given the ubiquitous nature of this virus and the challenging 
      precedent of correlating antiviral antibodies with disease association, these 
      antibody studies have been supported by the detection of HHV-6 DNA from samples 
      of MS serum as a marker of active viral infection.
FAU - Soldan, S S
AU  - Soldan SS
AD  - Viral Immunology Section, National Institute of Neurological Disorders and 
      Stroke, Bethesda, Maryland 20892, USA.
FAU - Berti, R
AU  - Berti R
FAU - Salem, N
AU  - Salem N
FAU - Secchiero, P
AU  - Secchiero P
FAU - Flamand, L
AU  - Flamand L
FAU - Calabresi, P A
AU  - Calabresi PA
FAU - Brennan, M B
AU  - Brennan MB
FAU - Maloni, H W
AU  - Maloni HW
FAU - McFarland, H F
AU  - McFarland HF
FAU - Lin, H C
AU  - Lin HC
FAU - Patnaik, M
AU  - Patnaik M
FAU - Jacobson, S
AU  - Jacobson S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antigens, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hepatitis Antibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Viral Proteins)
RN  - 138415-18-6 (p41 protein, Human herpesvirus 6)
SB  - IM
CIN - Nat Med. 1997 Dec;3(12):1321-2. PMID: 9396597
CIN - Nat Med. 1998 May;4(5):537; author reply 538. PMID: 9585208
CIN - Nat Med. 1998 May;4(5):537-8. PMID: 9585209
MH  - Antigens, Viral/immunology
MH  - DNA, Viral/*blood
MH  - DNA-Binding Proteins/immunology
MH  - Hepatitis Antibodies/*blood/immunology
MH  - Herpesviridae Infections/*complications
MH  - Herpesvirus 6, Human/genetics/immunology/isolation & purification/*physiology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Multiple Sclerosis/blood/immunology/*virology
MH  - Viral Proteins/immunology
EDAT- 1997/12/13 00:00
MHDA- 1997/12/13 00:01
CRDT- 1997/12/13 00:00
PHST- 1997/12/13 00:00 [pubmed]
PHST- 1997/12/13 00:01 [medline]
PHST- 1997/12/13 00:00 [entrez]
AID - 10.1038/nm1297-1394 [doi]
PST - ppublish
SO  - Nat Med. 1997 Dec;3(12):1394-7. doi: 10.1038/nm1297-1394.