PMID- 9396779
OWN - NLM
STAT- MEDLINE
DCOM- 19980113
LR  - 20240213
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 186
IP  - 12
DP  - 1997 Dec 15
TI  - TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new 
      TNF family member predominantly expressed in T cells, is a dendritic 
      cell-specific survival factor.
PG  - 2075-80
AB  - TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine) is a new 
      member of the TNF family that is induced upon T cell receptor engagement and 
      activates c-Jun N-terminal kinase (JNK) after interaction with its putative 
      receptor (TRANCE-R). In addition, TRANCE expression is restricted to lymphoid 
      organs and T cells. Here, we show that high levels of TRANCE-R are detected on 
      mature dendritic cells (DCs) but not on freshly isolated B cells, T cells, or 
      macrophages. Signaling by TRANCE-R appears to be dependent on TNF 
      receptor-associated factor 2 (TRAF2), since JNK induction is impaired in cells 
      from transgenic mice overexpressing a dominant negative TRAF2 protein. TRANCE 
      inhibits apoptosis of mouse bone marrow-derived DCs and human monocyte-derived 
      DCs in vitro. The resulting increase in DC survival is accompanied by a 
      proportional increase in DC-mediated T cell proliferation in a mixed leukocyte 
      reaction. TRANCE upregulates Bcl-xL expression, suggesting a potential mechanism 
      for enhanced DC survival. TRANCE does not induce the proliferation of or increase 
      the survival of T or B cells. Therefore, TRANCE is a new DC-restricted survival 
      factor that mediates T cell-DC communication and may provide a tool to 
      selectively enhance DC activity.
FAU - Wong, B R
AU  - Wong BR
AD  - Laboratory of Immunology, The Rockefeller University, New York 10021, USA.
FAU - Josien, R
AU  - Josien R
FAU - Lee, S Y
AU  - Lee SY
FAU - Sauter, B
AU  - Sauter B
FAU - Li, H L
AU  - Li HL
FAU - Steinman, R M
AU  - Steinman RM
FAU - Choi, Y
AU  - Choi Y
LA  - eng
SI  - GENBANK/AF013170
GR  - GM-07739/GM/NIGMS NIH HHS/United States
GR  - AI-13013/AI/NIAID NIH HHS/United States
GR  - CA-525133/CA/NCI NIH HHS/United States
GR  - T32 GM007739/GM/NIGMS NIH HHS/United States
GR  - R01 AI013013/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (BCL2L1 protein, human)
RN  - 0 (Bcl2l1 protein, mouse)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (RANK Ligand)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor Activator of Nuclear Factor-kappa B)
RN  - 0 (TNFRSF11A protein, human)
RN  - 0 (TNFSF11 protein, human)
RN  - 0 (Tnfrsf11a protein, mouse)
RN  - 0 (Tnfsf11 protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (bcl-X Protein)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - B-Lymphocytes/cytology
MH  - Bone Marrow Cells/cytology
MH  - CD40 Ligand
MH  - *Carrier Proteins
MH  - Cell Separation
MH  - Cell Survival
MH  - Cytokines/*physiology
MH  - Dendritic Cells/*cytology
MH  - Flow Cytometry
MH  - Humans
MH  - Membrane Glycoproteins/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Proto-Oncogene Proteins c-bcl-2/biosynthesis/genetics
MH  - RANK Ligand
MH  - RNA, Messenger/metabolism
MH  - Receptor Activator of Nuclear Factor-kappa B
MH  - T-Lymphocytes/cytology
MH  - Tumor Necrosis Factor-alpha/*physiology
MH  - Up-Regulation
MH  - bcl-X Protein
PMC - PMC2199171
EDAT- 1998/02/12 00:00
MHDA- 1998/02/12 00:01
PMCR- 1998/06/15
CRDT- 1998/02/12 00:00
PHST- 1998/02/12 00:00 [pubmed]
PHST- 1998/02/12 00:01 [medline]
PHST- 1998/02/12 00:00 [entrez]
PHST- 1998/06/15 00:00 [pmc-release]
AID - 10.1084/jem.186.12.2075 [doi]
PST - ppublish
SO  - J Exp Med. 1997 Dec 15;186(12):2075-80. doi: 10.1084/jem.186.12.2075.