PMID- 9397198
OWN - NLM
STAT- MEDLINE
DCOM- 19980102
LR  - 20190914
IS  - 0270-4137 (Print)
IS  - 0270-4137 (Linking)
VI  - 33
IP  - 4
DP  - 1997 Dec 1
TI  - Caloric restriction diminishes the age-associated loss of immunoreactive catalase 
      in rat prostate.
PG  - 256-63
AB  - BACKGROUND: Caloric restriction (CR) retards aging and diseases in mice, rats, 
      and other animals by unknown mechanisms. A popular hypothesis is that CR acts by 
      opposing age-associated increases in oxidative stress. METHODS: Because 
      influences of CR on antioxidant enzymes in the prostate have not been previously 
      investigated, immunohistologic methods (light and electron microscopy) were used 
      to determine the prostatic localization of catalase (CAT) in rats of diverse ages 
      (3-32 months) fed either normally or subjected to CR from age 16 months. RESULTS: 
      In 20-month-old rats fed either diet, CAT appeared as dense deposits at the 
      apical poles of the epithelium in the lateral lobes, and within the ductular 
      lumens, suggesting that CAT is secreted. Confirmation of both liver peroxisomal 
      and prostatic apical cytoplasmic localization of CAT was provided by electron 
      microscopic immunogold staining. The amount of CAT was reduced at 30 months in 
      normally fed rats but not in those on CR. CONCLUSIONS: CAT appears to be a 
      secretory product of the epithelial cells in the lateral lobes of the rat 
      prostate. Further, CR from late-middle age opposed the age-associated loss of 
      this intracellular enzyme activity.
FAU - Suzuki, K
AU  - Suzuki K
AD  - Department of Medicine, University of Wisconsin Medical School, Madison, USA.
FAU - Oberley, T D
AU  - Oberley TD
FAU - Pugh, T D
AU  - Pugh TD
FAU - Sempf, J M
AU  - Sempf JM
FAU - Weindruch, R
AU  - Weindruch R
LA  - eng
GR  - K01 AG 00650/AG/NIA NIH HHS/United States
GR  - R01 AG 10536/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
RN  - 0 (Antioxidants)
RN  - 0 (Immune Sera)
RN  - EC 1.11.1.6 (Catalase)
SB  - IM
MH  - Aging/*metabolism/physiology
MH  - Animals
MH  - Antioxidants/analysis
MH  - Blotting, Western
MH  - Body Weight/physiology
MH  - Catalase/*analysis/immunology
MH  - Cytoplasm/enzymology
MH  - *Diet, Reducing
MH  - Energy Intake/*physiology
MH  - Epithelial Cells/chemistry/enzymology/pathology
MH  - Immune Sera/immunology
MH  - Immunohistochemistry
MH  - Liver/enzymology
MH  - Male
MH  - Organ Size
MH  - Prostate/chemistry/*enzymology/physiology
MH  - Rats
MH  - Rats, Wistar
EDAT- 1997/12/16 02:44
MHDA- 2000/06/20 09:00
CRDT- 1997/12/16 02:44
PHST- 1997/12/16 02:44 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/12/16 02:44 [entrez]
AID - 10.1002/(SICI)1097-0045(19971201)33:4<256::AID-PROS6>3.0.CO;2-F [pii]
AID - 10.1002/(sici)1097-0045(19971201)33:4<256::aid-pros6>3.0.co;2-f [doi]
PST - ppublish
SO  - Prostate. 1997 Dec 1;33(4):256-63. doi: 
      10.1002/(sici)1097-0045(19971201)33:4<256::aid-pros6>3.0.co;2-f.