PMID- 9398739
OWN - NLM
STAT- MEDLINE
DCOM- 19980113
LR  - 20220409
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 82
IP  - 12
DP  - 1997 Dec
TI  - Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis 
      factor-alpha, in vivo.
PG  - 4196-200
AB  - We measured arterio-venous differences in concentrations of tumor necrosis 
      factor-alpha (TNF alpha) and interleukin-6 (IL-6) across a sc adipose tissue bed 
      in the postabsorptive state in 39 subjects [22 women and 17 men; median age, 36 
      yr (interquartile range, 26-48 yr); body mass index, 31.8 kg/m2 (range, 22.3- 
      38.7 kg/m2); percent body fat, 28.7% (range, 17.6-50.7%)]. A subgroup of 8 
      subjects had arteriovenous differences measured across forearm muscle. Thirty 
      subjects were studied from late morning to early evening; 19 ate a high 
      carbohydrate meal around 1300 h, and 11 continued to fast. We found a greater 
      than 2-fold increase in IL-6 concentrations across the adipose tissue bed 
      [arterial, 2.27 pg/mL (range, 1.42-3.53 pg/mL); venous, 6.71 pg/mL (range, 
      3.36-9.62 pg/mL); P < 0.001], but not across forearm muscle. Arterial plasma 
      concentrations of IL-6 correlated significantly with body mass index (Spearman's 
      r = 0.48; P < 0.01) and percent body fat (Spearman's r = 0.49; P < 0.01). 
      Subcutaneous adipose tissue IL-6 production increased by the early evening 
      (1800-1900 h) in both subjects who had extended their fasting and those who had 
      eaten. Neither deep forearm nor sc adipose tissue consistently released TNF alpha 
      [across adipose tissue: arterial, 1.83 pg/mL (range, 1.36-2.34 pg/mL); venous, 
      1.85 pg/mL (range, 1.44-2.53 pg/mL); P = NS: across forearm muscle: arterial, 
      1.22 pg/mL (range, 0.74-2.76 pg/mL); venous, 0.99 pg/mL (range, 0.69-1.70 pg/mL); 
      P = NS]. Although both IL-6 and TNF alpha are expressed by adipose tissue, our 
      results show that there are important differences in their systemic release. TNF 
      alpha is not released by this sc depot. In contrast, IL-6 is released from the 
      depot and is thereby able to signal systemically.
FAU - Mohamed-Ali, V
AU  - Mohamed-Ali V
AD  - University College London Medical School, United Kingdom.
FAU - Goodrick, S
AU  - Goodrick S
FAU - Rawesh, A
AU  - Rawesh A
FAU - Katz, D R
AU  - Katz DR
FAU - Miles, J M
AU  - Miles JM
FAU - Yudkin, J S
AU  - Yudkin JS
FAU - Klein, S
AU  - Klein S
FAU - Coppack, S W
AU  - Coppack SW
LA  - eng
GR  - DK-38092/DK/NIDDK NIH HHS/United States
GR  - DK-49989/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Abdomen/blood supply
MH  - Adipose Tissue/*metabolism
MH  - Adult
MH  - Arteries
MH  - Female
MH  - Forearm/blood supply
MH  - Humans
MH  - Interleukin-6/biosynthesis/blood/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Osmolar Concentration
MH  - Skin
MH  - Tumor Necrosis Factor-alpha/analysis/biosynthesis/*metabolism
MH  - Veins
EDAT- 1997/12/17 00:00
MHDA- 1997/12/17 00:01
CRDT- 1997/12/17 00:00
PHST- 1997/12/17 00:00 [pubmed]
PHST- 1997/12/17 00:01 [medline]
PHST- 1997/12/17 00:00 [entrez]
AID - 10.1210/jcem.82.12.4450 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1997 Dec;82(12):4196-200. doi: 10.1210/jcem.82.12.4450.