PMID- 9403060
OWN - NLM
STAT- MEDLINE
DCOM- 19980113
LR  - 20071114
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 46
IP  - 1
DP  - 1997 Nov 15
TI  - Identification of new translocation breakpoints at 12q13 in lipomas.
PG  - 70-7
AB  - Cytogenetic studies of banded chromosomes and fluorescence in situ hybridization 
      (FISH) of several yeast artificial chromosomes (YACs) that are part of a 128-kb 
      resolution physical map of a portion of 12q13 revealed that 4/14 (28%) lipomas 
      have breakpoints in 12q13. These breakpoints are more than 10 Mb away from the 
      HMGIC gene at 12q14-q15, which is known to be modified in some lipomas. FISH with 
      individual YACs at 12q13 enabled us to identify four YACs that span three 
      breakpoints. Our results suggest that genes other than HMGIC on human chromosome 
      12 may be involved in the etiology of lipoma development.
FAU - Merscher, S
AU  - Merscher S
AD  - Laboratoire de Genetique Chromosomique des Tumeurs, Faculte de Medecine, UMR 
      6549, CNRS/UNSA, Nice, France.
FAU - Marondel, I
AU  - Marondel I
FAU - Pedeutour, F
AU  - Pedeutour F
FAU - Gaudray, P
AU  - Gaudray P
FAU - Kucherlapati, R
AU  - Kucherlapati R
FAU - Turc-Carel, C
AU  - Turc-Carel C
LA  - eng
GR  - HG00380/HG/NHGRI NIH HHS/United States
GR  - HG00965/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
SB  - IM
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Genes, Neoplasm/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lipoma/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 1997/12/24 00:00
MHDA- 1997/12/24 00:01
CRDT- 1997/12/24 00:00
PHST- 1997/12/24 00:00 [pubmed]
PHST- 1997/12/24 00:01 [medline]
PHST- 1997/12/24 00:00 [entrez]
AID - S0888-7543(97)94993-4 [pii]
AID - 10.1006/geno.1997.4993 [doi]
PST - ppublish
SO  - Genomics. 1997 Nov 15;46(1):70-7. doi: 10.1006/geno.1997.4993.