PMID- 9403975
OWN - NLM
STAT- MEDLINE
DCOM- 19980122
LR  - 20190826
IS  - 0304-4017 (Print)
IS  - 0304-4017 (Linking)
VI  - 72
IP  - 1
DP  - 1997 Sep
TI  - Comparative persistent efficacy of doramectin, ivermectin and fenbendazole 
      against natural nematode infections in cattle.
PG  - 33-41
AB  - A study was conducted in Argentina, to investigate the period of protection of a 
      single injection of doramectin administered subcutaneously (s.c.) at 200 
      micrograms kg-1 (1 ml/50 kg) compared with single treatments of ivermectin (200 
      micrograms kg-1 s.c.) and fenbendazole (5 mg kg-1 p.o.), against field infections 
      of gastrointestinal parasites of cattle. Eighty-three animals were selected and 
      ranked on the basis of serial fecal egg counts (e.p.g.'s). From this group, three 
      animals were slaughtered before treatment and their lungs, abomasum, small and 
      large intestines, were processed for parasite counts and identification. The 
      remaining 80 animals were allocated in ranked groups of four to a control or one 
      of three treated groups. Animals of the four groups were grazed together in the 
      same pasture for the duration of the study. Treatments were administered on Day 
      0. Individual fecal samples were collected at weekly intervals for the first 49 
      days post-treatment and twice a week from Day 52 to Day 84 (end of study). At 
      each collection day fecal samples were pooled for coprocultures. On Day 28 and 
      56, two animals from each group, previously identified on Day 0, were killed and 
      their parasite burdens determined. The duration of protection of a single 
      injection of doramectin was longer than ivermectin or fenbendazole treatment. On 
      Day 56, the total number of parasites found in doramectin-treated animals was 
      significantly (P < 0.05) lower than parasite burdens found in either ivermectin- 
      or fenbendazole-treated animals. The longer persistent activity of doramectin was 
      expressed by the lower number of adults and L4 stages of Ostertagia ostertagi. 
      Data from this experiment demonstrated the limitations of using fecal egg counts 
      to evaluate the persistent efficacy of anthelmintics. The duration of activity of 
      doramectin was demonstrated more accurately by parasite counts in cattle from 
      each group since decreasing e.p.g.'s were seen in non-medicated animals without 
      changes in total parasite burdens.
FAU - Eddi, C
AU  - Eddi C
AD  - Instituto de Patabiologia, CICV-INTA, Moron, Argentina.
FAU - Muniz, R A
AU  - Muniz RA
FAU - Caracostantogolo, J
AU  - Caracostantogolo J
FAU - Errecalde, J O
AU  - Errecalde JO
FAU - Rew, R S
AU  - Rew RS
FAU - Michener, S L
AU  - Michener SL
FAU - McKenzie, M E
AU  - McKenzie ME
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - 0 (Anthelmintics)
RN  - 621BVT9M36 (Fenbendazole)
RN  - 70288-86-7 (Ivermectin)
RN  - KGD7A54H5P (doramectin)
SB  - IM
MH  - Animals
MH  - Anthelmintics/administration & dosage/*therapeutic use
MH  - Cattle
MH  - *Cattle Diseases
MH  - Feces/parasitology
MH  - Female
MH  - Fenbendazole/administration & dosage/*therapeutic use
MH  - Gastrointestinal Diseases/parasitology/prevention & control/*veterinary
MH  - Injections, Subcutaneous
MH  - Ivermectin/administration & dosage/*analogs & derivatives/*therapeutic use
MH  - Male
MH  - Nematode Infections/prevention & control/*veterinary
MH  - Orchiectomy
MH  - Parasite Egg Count
EDAT- 1997/12/24 00:00
MHDA- 1997/12/24 00:01
CRDT- 1997/12/24 00:00
PHST- 1997/12/24 00:00 [pubmed]
PHST- 1997/12/24 00:01 [medline]
PHST- 1997/12/24 00:00 [entrez]
AID - S0304401797000769 [pii]
AID - 10.1016/s0304-4017(97)00076-9 [doi]
PST - ppublish
SO  - Vet Parasitol. 1997 Sep;72(1):33-41. doi: 10.1016/s0304-4017(97)00076-9.