PMID- 9404715
OWN - NLM
STAT- MEDLINE
DCOM- 19980129
LR  - 20071114
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 50
IP  - 4
DP  - 1997 Nov 15
TI  - Similar pattern of MCP-1 expression in spinal cords and eyes of Lewis rats with 
      experimental autoimmune encephalomyelitis associated anterior uveitis.
PG  - 531-8
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokine family 
      responsible for the recruitment of T cells that have been found during 
      inflammation of the spinal cord in experimental autoimmune encephalomyelitis 
      (EAE) in Lewis rats immunized with myelin basic protein (MBP). Lewis rats 
      injected with MBP also developed anterior uveitis (AU), which coincided with the 
      onset of EAE. In the present studies, we examined the expression and distribution 
      of MCP-1 in the eye and spinal cord during disease and compared it to the 
      expression of Th1 cell type cytokines. Initially, MCP-1 expression was detected 
      at the preclinical phase in the iris/ciliary body and lumbar spinal cord and 
      increased during the course of EAE/AU. Mononuclear infiltrating cells and 
      endothelial cells and astrocytes of the CNS could be identified as a source of 
      MCP-1 by in situ hybridization. Kinetics of expression of Th1 characteristic 
      cytokines such as IL-2 and IFNgamma was in agreement with the expression of MCP-1 
      chemokine. Moreover, induction of the gene expression of MCP-1 seemed to occur 
      earlier than that of MIP-2, and it correlated with increasing disease severity. 
      MCP-1 seems to contribute to the initial recruitment of inflammatory cells into 
      both the tissues of the eye and CNS over the course of disease.
FAU - Adamus, G
AU  - Adamus G
AD  - R.S. Dow Neurological Sciences Institute, Legacy-Good Samaritan Hospital and 
      Medical Center, Portland, Oregon, USA. adamusg@lhs.org
FAU - Machnicki, M
AU  - Machnicki M
FAU - Amundson, D
AU  - Amundson D
FAU - Adlard, K
AU  - Adlard K
FAU - Offner, H
AU  - Offner H
LA  - eng
GR  - EY 10316/EY/NEI NIH HHS/United States
GR  - NS 23444/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Eye Proteins)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/metabolism
MH  - Chemokine CCL2/*biosynthesis
MH  - Chemokines/metabolism
MH  - Cytokines/biosynthesis
MH  - Encephalomyelitis, Autoimmune, Experimental/*metabolism
MH  - Eye Proteins/*biosynthesis
MH  - Female
MH  - Nerve Tissue Proteins/*biosynthesis
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Spinal Cord/*metabolism
MH  - Up-Regulation
MH  - Uveitis, Anterior/*metabolism
EDAT- 1997/12/24 01:15
MHDA- 2000/06/20 09:00
CRDT- 1997/12/24 01:15
PHST- 1997/12/24 01:15 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/12/24 01:15 [entrez]
AID - 10.1002/(SICI)1097-4547(19971115)50:4<531::AID-JNR4>3.0.CO;2-F [pii]
AID - 10.1002/(SICI)1097-4547(19971115)50:4<531::AID-JNR4>3.0.CO;2-F [doi]
PST - ppublish
SO  - J Neurosci Res. 1997 Nov 15;50(4):531-8. doi: 
      10.1002/(SICI)1097-4547(19971115)50:4<531::AID-JNR4>3.0.CO;2-F.