PMID- 9404831
OWN - NLM
STAT- MEDLINE
DCOM- 19971230
LR  - 20170214
IS  - 0003-3197 (Print)
IS  - 0003-3197 (Linking)
VI  - 48
IP  - 12
DP  - 1997 Dec
TI  - Acute electrophysiological effects of dipyridamole on sinus node function in 
      patients with sick sinus syndrome.
PG  - 1051-4
AB  - One of the most widely used tests for evaluation of sinus node function is sinus 
      node recovery time (SNRT), which requires right heart catheterization. On the 
      other hand SNRT has high specificity but only moderate sensitivity in the 
      diagnosis of sick sinus syndrome (SSS). The authors studied acute 
      electrophysiologic effects of dipyridamole (0.40 mg/kg IV) in 16 patients with 
      clinical SSS. All of them had normal SNRT and had undergone permanent DDD 
      pacemaker implantation. By the aid of temporary pacing inhibition, the authors 
      noninvasively measured the corrected sinus node recovery time (SNRTc) and sinus 
      cycle length (SCL) before and after dipyridamole administration. SCL was slightly 
      decreased from a mean basal value of 1025 +/-323 to 913+/-213 msec after 
      dipyridamole administration (mean -10%), but this was not statistically 
      significant. SNRTc was increased from a mean basal value of 344+/-91 to 606+/-156 
      msec after dipyridamole administration (+76% P< or =0.004). These results suggest 
      that dipyridamole must be used cautiously in patients with SSS. Intravenous 
      dipyridamole may be a useful test to assess sinus node function. SNRT measurement 
      after intravenous dipyridamole may increase sensitivity of this test in patients 
      with suspected SSS and normal SNRT.
FAU - Yesil, M
AU  - Yesil M
AD  - Cardiology Department, Izmir State Hospital, Turkey.
FAU - Bayata, S
AU  - Bayata S
FAU - Postaci, N
AU  - Postaci N
FAU - Aydin, C
AU  - Aydin C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Vasodilator Agents)
RN  - 64ALC7F90C (Dipyridamole)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Dipyridamole/administration & dosage
MH  - Electrophysiology
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial
MH  - Sensitivity and Specificity
MH  - Sick Sinus Syndrome/*diagnosis/physiopathology/therapy
MH  - Sinoatrial Node/*drug effects/physiopathology
MH  - *Vasodilator Agents/administration & dosage
EDAT- 1997/12/24 00:00
MHDA- 1997/12/24 00:01
CRDT- 1997/12/24 00:00
PHST- 1997/12/24 00:00 [pubmed]
PHST- 1997/12/24 00:01 [medline]
PHST- 1997/12/24 00:00 [entrez]
AID - 10.1177/000331979704801205 [doi]
PST - ppublish
SO  - Angiology. 1997 Dec;48(12):1051-4. doi: 10.1177/000331979704801205.