PMID- 9407457
OWN - NLM
STAT- MEDLINE
DCOM- 19980205
LR  - 20181201
IS  - 0098-6577 (Print)
IS  - 0098-6577 (Linking)
VI  - 63
DP  - 1997 Dec
TI  - Urinary excretion of TGF-beta 1, PDGF-BB and fibronectin in insulin-dependent 
      diabetes mellitus patients.
PG  - S195-7
AB  - We studied the urinary excretion of transforming growth factor-beta 1 (TGF-beta 
      1), platelet-derived growth factor-BB (PDGF) and fibronectin (FN) in 104 patients 
      (52 normoalbuminuric, 24 microalbuminuric, and 28 with overt diabetic 
      nephropathy) with insulin-dependent diabetes mellitus (IDDM) of a long duration 
      and in 30 non-diabetic controls. IDDM patients had higher urinary excretion of 
      TGF-beta 1, PDGF and FN compared to controls. Urinary excretion of TGF-beta 1 and 
      PDGF was elevated in all IDDM subgroups, while FN excretion was significantly 
      increased only in patients with macroalbuminuria. Urinary excretion of TGF-beta 1 
      and FN did not differ between normoalbuminuric IDDM patients with long duration 
      of diabetes, a group at low risk of ever developing diabetic nephropathy, and 
      IDDM patients with incipient or overt diabetic nephropathy. Excretion of PDGF was 
      significantly higher in patients with micro- and macroalbuminuria compared to 
      normoalbuminuric patients, but there was a considerable overlap between the 
      groups. In conclusion, although longitudinal follow-up studies are needed to 
      further clarify the issue, our results in long-standing IDDM do not support a 
      hypothesis of urinary excretion of TGF-beta 1, PDGF or FN to predict development 
      of diabetic nephropathy.
FAU - Fagerudd, J A
AU  - Fagerudd JA
AD  - Department of Medicine, Helsinki University Central Hospital, Finland.
FAU - Groop, P H
AU  - Groop PH
FAU - Honkanen, E
AU  - Honkanen E
FAU - Teppo, A M
AU  - Teppo AM
FAU - Gronhagen-Riska, C
AU  - Gronhagen-Riska C
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Kidney Int Suppl
JT  - Kidney international. Supplement
JID - 7508622
RN  - 0 (Anticoagulants)
RN  - 0 (Fibronectins)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Proto-Oncogene Proteins c-sis)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transforming Growth Factor beta)
RN  - 1B56C968OA (Becaplermin)
SB  - IM
MH  - Adult
MH  - Albuminuria/urine
MH  - Anticoagulants/*urine
MH  - Becaplermin
MH  - Diabetes Mellitus, Type 2/*urine
MH  - Diabetic Nephropathies/urine
MH  - Female
MH  - Fibronectins/*urine
MH  - Humans
MH  - Male
MH  - Platelet-Derived Growth Factor/*urine
MH  - Proto-Oncogene Proteins c-sis
MH  - Recombinant Proteins/urine
MH  - Transforming Growth Factor beta/*urine
EDAT- 1998/01/04 00:00
MHDA- 1998/01/04 00:01
CRDT- 1998/01/04 00:00
PHST- 1998/01/04 00:00 [pubmed]
PHST- 1998/01/04 00:01 [medline]
PHST- 1998/01/04 00:00 [entrez]
PST - ppublish
SO  - Kidney Int Suppl. 1997 Dec;63:S195-7.