PMID- 9407709
OWN - NLM
STAT- MEDLINE
DCOM- 19980112
LR  - 20231221
IS  - 0065-1400 (Print)
IS  - 0065-1400 (Linking)
VI  - 57
IP  - 3
DP  - 1997
TI  - CGP 42112A abolishes facilitation of recognition caused by angiotensin II and 
      angiotensin II(3-7) in rats.
PG  - 227-34
LID - 1230 [pii]
LID - 10.55782/ane-1997-1230 [doi]
AB  - The role of the angiotensin AT2 receptors in some behavioural effects of 
      angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective 
      antagonist CGP 42112A, was assessed. Ang II and Ang II(3-7), given 
      intracerebroventricularly (icv) at the dose of 1 nmole each, substantially 
      improved object recognition memory and enhanced apomorphine (1 mg/kg) stereotypy. 
      Pre-treatment of rats with CGP 42112A (2 micrograms), per se ineffective in all 
      tests, abolished activity of both peptides. None of the treatments significantly 
      changed behaviour of rats in open field. The results point to the considerable 
      involvement of the AT2 angiotensin receptors in the improvement of recognition 
      memory caused by Ang II and Ang II(3-7).
FAU - Braszko, J J
AU  - Braszko JJ
AD  - Department of Pharmacology, Medical Academy of Bialystok, Poland.
FAU - Kulakowska, A
AU  - Kulakowska A
FAU - Winnicka, M M
AU  - Winnicka MM
FAU - Karwowska-Polecka, W
AU  - Karwowska-Polecka W
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Oligopeptides)
RN  - 0 (Peptide Fragments)
RN  - 11128-99-7 (Angiotensin II)
RN  - 122483-84-5 (angiotensin II (3-7))
RN  - 127060-75-7 (CGP 42112A)
SB  - IM
MH  - Angiotensin II/*physiology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Locomotion/drug effects
MH  - Male
MH  - Memory/drug effects/physiology
MH  - Oligopeptides/*pharmacology
MH  - Pattern Recognition, Visual/*drug effects/*physiology
MH  - Peptide Fragments/*physiology
MH  - Rats
MH  - Rats, Wistar
EDAT- 1997/01/01 00:00
MHDA- 1998/01/04 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/01/04 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 1230 [pii]
AID - 10.55782/ane-1997-1230 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 1997;57(3):227-34. doi: 10.55782/ane-1997-1230.