PMID- 9407947
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20041117
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 57
IP  - 24
DP  - 1997 Dec 15
TI  - Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
PG  - 5446-51
AB  - Although pituitary adenomas are monoclonal proliferations, somatic mutations 
      involving genes that govern cell proliferation or hormone production have been 
      difficult to identify. The genetic etiology of most pituitary tumors, therefore, 
      remains unknown. Pituitary adenomas can develop sporadically or as a part of 
      multiple endocrine neoplasia type 1 (MEN1). Recently, the gene responsible for 
      MEN1 was cloned. To elucidate the potential etiological role of the MEN1 gene in 
      pituitary tumorigenesis, 39 sporadic pituitary adenomas from 38 patients and 1 
      pituitary adenoma from a familial MEN1 patient were examined for MEN1 gene 
      mutations and allelic deletions. Four of 39 sporadic pituitary adenomas showed a 
      deletion of one copy of the MEN1 gene, and a specific MEN1 gene mutation in the 
      remaining gene copy was detected in 2 of these tumors. The corresponding 
      germ-line sequence was normal in all sporadic cases. A specific MEN1 mutation was 
      detected in a pituitary adenoma and corresponding germ-line DNA in a patient with 
      familial MEN1. An allelic deletion of the remaining copy of the MEN1 gene was 
      also found in the patient's tumor. Genetic alterations of the MEN1 gene represent 
      a candidate pathogenetic mechanism of pituitary tumorigenesis. The data suggest 
      that somatic MEN1 gene mutations and deletions play a causative role in the 
      development of a subgroup of sporadic pituitary adenomas.
FAU - Zhuang, Z
AU  - Zhuang Z
AD  - Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 
      20892, USA.
FAU - Ezzat, S Z
AU  - Ezzat SZ
FAU - Vortmeyer, A O
AU  - Vortmeyer AO
FAU - Weil, R
AU  - Weil R
FAU - Oldfield, E H
AU  - Oldfield EH
FAU - Park, W S
AU  - Park WS
FAU - Pack, S
AU  - Pack S
FAU - Huang, S
AU  - Huang S
FAU - Agarwal, S K
AU  - Agarwal SK
FAU - Guru, S C
AU  - Guru SC
FAU - Manickam, P
AU  - Manickam P
FAU - Debelenko, L V
AU  - Debelenko LV
FAU - Kester, M B
AU  - Kester MB
FAU - Olufemi, S E
AU  - Olufemi SE
FAU - Heppner, C
AU  - Heppner C
FAU - Crabtree, J S
AU  - Crabtree JS
FAU - Burns, A L
AU  - Burns AL
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Marx, S J
AU  - Marx SJ
FAU - Chandrasekharappa, S C
AU  - Chandrasekharappa SC
FAU - Collins, F S
AU  - Collins FS
FAU - Emmert-Buck, M R
AU  - Emmert-Buck MR
FAU - Liotta, L A
AU  - Liotta LA
FAU - Asa, S L
AU  - Asa SL
FAU - Lubensky, I A
AU  - Lubensky IA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
SB  - IM
MH  - Adenoma/*genetics
MH  - Adult
MH  - Aged
MH  - Child, Preschool
MH  - Female
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - *Mutation
MH  - Pituitary Neoplasms/*genetics
EDAT- 1998/01/04 00:00
MHDA- 1998/01/04 00:01
CRDT- 1998/01/04 00:00
PHST- 1998/01/04 00:00 [pubmed]
PHST- 1998/01/04 00:01 [medline]
PHST- 1998/01/04 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1997 Dec 15;57(24):5446-51.