PMID- 9408184
OWN - NLM
STAT- MEDLINE
DCOM- 19980130
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 58
IP  - 4
DP  - 1997 Dec
TI  - Differential effects of beta-endorphin and Met- and Leu-enkephalin on steroid 
      hormone-induced lordosis in ovariectomized female rats.
PG  - 837-42
AB  - The effect of intrathirdventricular (I.T.V.) injections of beta-endorphin, 
      anti-beta-endorphin antiserum, Met-enkephalin, Leu-enkephalin, and naloxone on 
      the initial activation and final development of steroid hormone-mediated 
      induction of female sexual receptivity was studied in ovariectomized female rats. 
      The lordosis response to male mounts in ovariectomized rats after subcutaneous 
      (S.C.) estradiol benzoate (EB) and progesterone (Prog) priming was facilitated by 
      beta-endorphin, and Met-enkephalin (10 microg x 5 microl(-1)), but inhibited by 
      Leu-enkephalin, when the peptides were injected into the third ventricle at the 
      time of S.C. EB priming. A lower dose Met-enkephalin had no effects. Lordosis 
      behavior in steroid hormone-primed rats was significantly facilitated when I.T.V. 
      injections of Met-enkephalin were given 1 h prior to behavioral testing (47 h 
      after EB priming). At 1 h prior to behavioral testing (47 h after EB priming), 
      I.T.V. injection of beta-endorphin significantly inhibited lordosis behavior, 
      especially at the higher dose of beta-endorphin (10 microg x 5 microl(-1)). Under 
      those conditions, Leu-enkephalin had no effect. Lordosis behavior of 
      ovariectomized female rats receiving S.C. steroid hormones and I.T.V. injection 
      of anti-beta-endorphin antiserum was significantly inhibited when 
      anti-beta-endorphin antiserum was injected at the time of EB priming. However, 
      lordosis was significantly facilitated when anti-beta-endorphin antiserum was 
      injected 1 h prior to the behavior testing (47 h after EB priming). In contrast, 
      I.T.V. injection of the opioid antagonist naloxone given either at the time of EB 
      priming or 1 h prior to behavioral testing (47 h after EB priming) decreased 
      lordosis behavior. The present results suggest that 1) beta-endorphin, 
      Met-enkephalin, and Leu-enkephalin have differential effects in the control of 
      lordosis behavior; 2) the opioidergic systems may modulate initial-stage and 
      final-stage estrogen-induced lordosis behavior; and 3) the opioidergic systems 
      could be divided into the endorphinergic modulation-type and enkephalinergic 
      modulation-type, based on their effects on lordosis behavior.
FAU - Torii, M
AU  - Torii M
AD  - Laboratory for Environmental Bioregulation, Faculty of Engineering, Kyushu 
      Institute of Technology, Fukuoka, Japan. torii@dhs.kyutech.ac.jp
FAU - Kubo, K
AU  - Kubo K
FAU - Sasaki, T
AU  - Sasaki T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Steroids)
RN  - 36B82AMQ7N (Naloxone)
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 60617-12-1 (beta-Endorphin)
SB  - IM
MH  - Animals
MH  - Enkephalin, Leucine/administration & dosage/*pharmacology
MH  - Enkephalin, Methionine/administration & dosage/*pharmacology
MH  - Female
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Ovariectomy
MH  - Posture/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sexual Behavior, Animal/*drug effects
MH  - Steroids/*antagonists & inhibitors/pharmacology
MH  - beta-Endorphin/administration & dosage/*pharmacology
EDAT- 1998/01/04 00:00
MHDA- 1998/01/04 00:01
CRDT- 1998/01/04 00:00
PHST- 1998/01/04 00:00 [pubmed]
PHST- 1998/01/04 00:01 [medline]
PHST- 1998/01/04 00:00 [entrez]
AID - S0091-3057(97)00018-X [pii]
AID - 10.1016/s0091-3057(97)00018-x [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1997 Dec;58(4):837-42. doi: 
      10.1016/s0091-3057(97)00018-x.