PMID- 9408595
OWN - NLM
STAT- MEDLINE
DCOM- 19980204
LR  - 20190909
IS  - 0387-7604 (Print)
IS  - 0387-7604 (Linking)
VI  - 19
IP  - 7
DP  - 1997 Nov
TI  - Early detection of axonal and neuronal lesions in prenatal-onset periventricular 
      leukomalacia.
PG  - 480-4
AB  - The expression of beta-amyloid precursor protein (beta-APP) immunoreactivity was 
      investigated in 16 cases of prenatal-onset periventricular leukomalacia (PVL). 
      beta-APP positive axons were found in the early stage of prenatal PVL, which 
      included coagulation necrosis, microglial activation, axonal swelling or 
      astrogliosis, but were not detectable in the late stage of prenatal PVL. 
      Furthermore, beta-APP immunoreactive neurons were also observed in the fifth 
      layer of pyramidal neurons of the cerebral cortex, corresponding to the beta-APP 
      positive axons in PVL. Thus, beta-APP is detected as an early sign of axonal and 
      neuronal lesions in prenatal-onset PVL, and neuronal beta-APP in the cerebral 
      cortex may function to repair cell damage. In addition, prenatal PVL occurred at 
      various stages before birth.
FAU - Meng, S Z
AU  - Meng SZ
AD  - Department of Mental Retardation and Birth Defect Research, National Institute of 
      Neuroscience, National Center of Neurology and Psychiatry.
FAU - Arai, Y
AU  - Arai Y
FAU - Deguchi, K
AU  - Deguchi K
FAU - Takashima, S
AU  - Takashima S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Amyloid beta-Protein Precursor/biosynthesis
MH  - Axons/*ultrastructure
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant, Newborn
MH  - Leukomalacia, Periventricular/metabolism/*pathology
MH  - Neurons/*ultrastructure
MH  - Pregnancy
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
AID - S0387-7604(97)00068-5 [pii]
AID - 10.1016/s0387-7604(97)00068-5 [doi]
PST - ppublish
SO  - Brain Dev. 1997 Nov;19(7):480-4. doi: 10.1016/s0387-7604(97)00068-5.