PMID- 9409445
OWN - NLM
STAT- MEDLINE
DCOM- 19980218
LR  - 20190914
IS  - 0303-8467 (Print)
IS  - 0303-8467 (Linking)
VI  - 99 Suppl 2
DP  - 1997 Oct
TI  - Analysis of class II genes of human leukocyte antigen in patients with moyamoya 
      disease.
PG  - S234-7
AB  - Moyamoya disease is a progressive steno-occlusive disease at the terminal portion 
      of the bilateral internal carotid arteries. An unusual vascular network is formed 
      as a result of ischemic change of cerebrovascular system. Although some 
      investigations suggested possible etiological factors of Moyamoya disease, the 
      etiology is still unknown. To elucidate the genetic factors of Moyamoya disease, 
      class II genes of human leukocyte antigen (HLA) were analyzed at the DNA level. 
      The DNA typing of HLA was performed in the unrelated Japanese patients with 
      definite Moyamoya disease using extracted genomic DNA from the leukocyte. The 
      genotype was confirmed by polymerase chain reaction-sequence specific 
      oligonucleotide probe (PCR-SSOP) technique. The class II genotypes were analyzed 
      in 71 samples. As a result, several alleles of class II genes showed significant 
      association with Moyamoya disease. DQB1*0502 had positive association with the 
      disease. On the other hand DRB1*0405 and DQB1*0401 had negative association. 
      Moyamoya disease seems to have a genetic background in its etiology because 
      certain alleles of HLA are associated with Moyamoya disease.
FAU - Inoue, T K
AU  - Inoue TK
AD  - Department of Neurosurgery, Faculty of Medicine, Kyushu University, Fukuoka, 
      Japan.
FAU - Ikezaki, K
AU  - Ikezaki K
FAU - Sasazuki, T
AU  - Sasazuki T
FAU - Matsushima, T
AU  - Matsushima T
FAU - Fukui, M
AU  - Fukui M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - *Alleles
MH  - Genotype
MH  - HLA Antigens/*genetics/*immunology
MH  - HLA-DR Antigens/*genetics/*immunology
MH  - Humans
MH  - Moyamoya Disease/*genetics/*immunology
MH  - Polymerase Chain Reaction
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
AID - S0303-8467(97)82360-8 [pii]
AID - 10.1016/s0303-8467(97)00051-6 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 1997 Oct;99 Suppl 2:S234-7. doi: 
      10.1016/s0303-8467(97)00051-6.