PMID- 940960
OWN - NLM
STAT- MEDLINE
DCOM- 19760925
LR  - 20151119
IS  - 0034-5164 (Print)
IS  - 0034-5164 (Linking)
VI  - 14
IP  - 2
DP  - 1976 Jun
TI  - Inhibition of human erythrocyte acetylcholinesterase by succinyldicholine.
PG  - 269-75
AB  - When human erythrocyte acetylcholinesterase (AChE) is inhibited by 
      succinyldicholine (SuCh) at low ionic strength, mu = 0.03, two apparent affinity 
      constants for the inhibitor can be distinguished, KI(1) = 5.4 X 10-5 M and KI(2) 
      = 1.3 X 10-5 M. Increasing the ionic strength to mu = 0.58 increases KI(1) to 1.1 
      X 10-4 M, but abolishes the contribution of KI(2) completely. It is suggested 
      that a similar process may underlie the apparently continuous variation in 
      affinity constant with ionic strength which has been reported for many 
      bifunctional cationic inhibitors. Since KI(2) is in a concentration range 
      commonly attained therapeutically, some of the clinical manifestations of 
      succinyldicholine administration, e.g., muscarinic effects, may be explained by 
      its anticholinesterase action.
FAU - Lanks, K W
AU  - Lanks KW
FAU - Sklar, G S
AU  - Sklar GS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Res Commun Chem Pathol Pharmacol
JT  - Research communications in chemical pathology and pharmacology
JID - 0244734
RN  - 0 (Cholinesterase Inhibitors)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - J2R869A8YF (Succinylcholine)
SB  - IM
MH  - Acetylcholinesterase/blood
MH  - *Cholinesterase Inhibitors
MH  - Erythrocytes/*enzymology
MH  - Humans
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Sodium Chloride/pharmacology
MH  - Succinylcholine/*pharmacology
EDAT- 1976/06/01 00:00
MHDA- 1976/06/01 00:01
CRDT- 1976/06/01 00:00
PHST- 1976/06/01 00:00 [pubmed]
PHST- 1976/06/01 00:01 [medline]
PHST- 1976/06/01 00:00 [entrez]
PST - ppublish
SO  - Res Commun Chem Pathol Pharmacol. 1976 Jun;14(2):269-75.