PMID- 9411030
OWN - NLM
STAT- MEDLINE
DCOM- 19971208
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 283
IP  - 2
DP  - 1997 Nov
TI  - Excitatory amino acid receptor antagonists block the cardiovascular and anxiety 
      responses elicited by gamma-aminobutyric acidA receptor blockade in the 
      basolateral amygdala of rats.
PG  - 969-77
AB  - Blockade of gamma-aminobutyric acid (GABAA) receptors in the anterior basolateral 
      amygdala (BLA) with bicuculline methiodide results in an increase in heart rate, 
      blood pressure and "anxiety" in rats. Glutamate receptors in the BLA are also 
      reported to be involved in eliciting anxiety responses. The purpose of this study 
      was to investigate the interaction between GABAergic inhibition and glutamatergic 
      excitation in the BLA. Male Wistar rts were implanted with femoral arterial 
      catheters and bilateral chronic microinjection cannulae into the BLA. Each animal 
      was injected with either artificial cerebrospinal fluid (100 nl), bicuculline 
      methiodide (10 pmol/100 nl) or bicuculline methiodide + one dose of an antagonist 
      of either the N-methyl-D-aspartate receptor [AP5 (20 and 100 pmol) and 
      dizocilpine (25 and 125 pmol)] or the non-N-methyl-D-aspartate ionotropic 
      receptor [CNQX (10 and 50 pmol) and GYKI 52466 (50 and 250 pmol)]. Increases in 
      heart rate, blood pressure and "anxiety" (as measured in the social interaction 
      test) observed in rats after bicuculline methiodide injections into the BLA were 
      blocked in a dose dependent manner with the concurrent injections of either 
      N-methyl-D-aspartate or non-N-methyl-D-aspartate antagonists, suggesting that 
      activation of both subtypes of glutamate ionotropic receptors may be necessary 
      for the responses elicited by GABAA receptor blockade in the basolateral 
      amygdala.
FAU - Sajdyk, T J
AU  - Sajdyk TJ
AD  - Department of Psychitry, Indiana University School of Medicine, Indianapolis, 
      Indiana 46202, USA.
FAU - Shekhar, A
AU  - Shekhar A
LA  - eng
GR  - MH 52691/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 102771-26-6 (GYKI 52466)
RN  - 12794-10-4 (Benzodiazepines)
RN  - 40709-69-1 (bicuculline methiodide)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Amygdala/*physiology
MH  - Animals
MH  - *Anti-Anxiety Agents
MH  - Anxiety/*prevention & control
MH  - Benzodiazepines/pharmacology
MH  - Bicuculline/analogs & derivatives/pharmacology
MH  - Dizocilpine Maleate/pharmacology
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - *GABA-A Receptor Antagonists
MH  - Hemodynamics/*drug effects
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1997 Nov;283(2):969-77.