PMID- 9412656
OWN - NLM
STAT- MEDLINE
DCOM- 19980106
LR  - 20211203
IS  - 0735-7907 (Print)
IS  - 0735-7907 (Linking)
VI  - 15
IP  - 6
DP  - 1997
TI  - Expression of the HGF/SF receptor, c-met, and its ligand in human colorectal 
      cancers.
PG  - 513-21
AB  - The c-met proto-oncogene product is a receptor tyrosine kinase that mediates the 
      effects of the multifunctional cytokine hepatocyte growth factor/scatter factor 
      (HGF/SF). We have studied the expression of both the c-met receptor and HGF/SF at 
      both the protein and message level in colorectal cancer tissues of varying 
      disease stage. All of the tumors displayed an overexpression of the c-met mRNA 
      compared to their normal tissue counterparts while 16 of 21 tissues (75%) 
      displayed up-regulation of c-met protein. No HGF/SF mRNA or protein could be 
      detected in either tissue type. Viable tumor cells extracted from cancer tissue 
      exhibited increased motility in response to HGF/SF stimulation demonstrating that 
      c-met was functionally active. No correlation between expression of c-met and 
      tumor stage or degree of differentiation was observed. HGF/SF is known to be a 
      potent stimulator of tumor cell motility and invasion, two cellular properties 
      essential for the metastatic development of cancers. The overexpression of the 
      HGF/SF receptor in colorectal cancers may result in an increased sensitivity to 
      HGF/SF, which may confer an enhanced metastatic potential to the cancer cells 
      within the tumor body.
FAU - Hiscox, S E
AU  - Hiscox SE
AD  - Department of Surgery, University of Wales College of Medicine, Heath Park, 
      Cardiff, U.K.
FAU - Hallett, M B
AU  - Hallett MB
FAU - Puntis, M C
AU  - Puntis MC
FAU - Nakamura, T
AU  - Nakamura T
FAU - Jiang, W G
AU  - Jiang WG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cancer Invest
JT  - Cancer investigation
JID - 8307154
RN  - 0 (Ligands)
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Colorectal Neoplasms/*metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Ligands
MH  - Neoplasm Staging
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-met/biosynthesis/*metabolism
MH  - RNA, Messenger/analysis
EDAT- 1997/01/01 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.3109/07357909709047592 [doi]
PST - ppublish
SO  - Cancer Invest. 1997;15(6):513-21. doi: 10.3109/07357909709047592.