PMID- 9413235
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20080409
IS  - 0828-282X (Print)
IS  - 0828-282X (Linking)
VI  - 13
IP  - 11
DP  - 1997 Nov
TI  - Midterm results with the Sorin Monostrut heart valve prosthesis.
PG  - 1039-44
AB  - OBJECTIVE: To monitor the hematological and clinical sequelae of a single tilting 
      disc cardiac valve prosthesis. DESIGN: Prospective nonrandomized trial. SETTING: 
      University teaching hospital. PARTICIPANTS: All patients receiving a single 
      mechanical cardiac valve prosthesis were offered the Sorin Monostrut valve if 
      they met the criteria for valve use. Seventy-five per cent of the patients 
      entered were in New York Heart Association (NYHA) functional class III or IV. One 
      hundred and forty-seven patients were subsequently followed at three months and 
      then yearly after valve implantation for seven years. MAIN OUTCOME MEASURES: At 
      one year, preoperative indexes of hemolysis were compared with three-month and 
      one-year postoperative values. Actuarial curves for survival, freedom from 
      cerebrovascular events and explantation were constructed for the seven-year 
      follow-up period. RESULTS: Hemolysis, as measured by lactate dehydrogenase 
      values, commonly occurs preoperatively, remaining significantly elevated three 
      months and one year following valve implantation. Serum haptoglobin was normal 
      preoperatively but was significantly low at one year. Anemia was uncommon and 
      most patients had normal reticulocyte counts at one year. At three years, 81% of 
      patients were in NYHA functional class I. CONCLUSIONS: Midterm results show that 
      this valve is structurally reliable and meets all current requirements for a safe 
      mechanical valve.
FAU - Forbes, C
AU  - Forbes C
AD  - Maritime Heart Center, Queen Elizabeth II Health Science Centre, Halifax, Nova 
      Scotia.
FAU - Ross, D
AU  - Ross D
FAU - Sullivan, J
AU  - Sullivan J
FAU - Ali, I
AU  - Ali I
FAU - Kinley, E
AU  - Kinley E
FAU - Wood, J
AU  - Wood J
FAU - Landymore, R
AU  - Landymore R
FAU - Murphy, D
AU  - Murphy D
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Haptoglobins)
RN  - 9011-92-1 (Hemosiderin)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Coronary Artery Bypass
MH  - Coronary Disease/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Haptoglobins/analysis
MH  - *Heart Valve Prosthesis/standards
MH  - *Heart Valve Prosthesis Implantation
MH  - Hemosiderin/analysis
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reticulocyte Count
MH  - Treatment Outcome
EDAT- 1997/12/31 00:00
MHDA- 1997/12/31 00:01
CRDT- 1997/12/31 00:00
PHST- 1997/12/31 00:00 [pubmed]
PHST- 1997/12/31 00:01 [medline]
PHST- 1997/12/31 00:00 [entrez]
PST - ppublish
SO  - Can J Cardiol. 1997 Nov;13(11):1039-44.