PMID- 9413274
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 80
IP  - 1-2
DP  - 1997 Dec
TI  - Combined effect of HLA-DRB1*1501 and interleukin-1 receptor antagonist gene 
      allele 2 in susceptibility to relapsing/remitting multiple sclerosis.
PG  - 172-8
AB  - Susceptibility to multiple sclerosis (MS) is associated with HLA-DRB1*1501. Many 
      reports have suggested associations with other loci but these results remain 
      unconfirmed. We studied the IL-1 receptor antagonist (IL-1ra) gene polymorphism 
      and the HLA-DR and DQ allele frequencies by DNA-based methods in both the primary 
      chronic progressive form (PP MS) and the relapsing/remitting form (R/R MS). The 
      frequency of DRB1*1501 and IL-1ra allele 2 were significantly higher in R/R MS. 
      Association was more marked in the female sex and in patients with benign forms 
      of R/R MS. On the other hand DR4 subtypes carrying a Val at position 86 in the DR 
      beta chain were increased in PP MS. The present study indicates that MS is 
      genetically heterogeneous and shows a combined effect of HLA-DR and IL-1ra genes 
      in susceptibility to the R/R form of the disease.
FAU - de la Concha, E G
AU  - de la Concha EG
AD  - Department of Immunology, San Carlos University Hospital, Madrid, Spain.
FAU - Arroyo, R
AU  - Arroyo R
FAU - Crusius, J B
AU  - Crusius JB
FAU - Campillo, J A
AU  - Campillo JA
FAU - Martin, C
AU  - Martin C
FAU - Varela de Seijas, E
AU  - Varela de Seijas E
FAU - Pena, A S
AU  - Pena AS
FAU - Claveria, L E
AU  - Claveria LE
FAU - Fernandez-Arquero, M
AU  - Fernandez-Arquero M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Sialoglycoproteins)
SB  - IM
MH  - *Alleles
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Male
MH  - Multiple Sclerosis/epidemiology/*genetics/*immunology
MH  - Random Allocation
MH  - Receptors, Interleukin-1/*antagonists & inhibitors/*genetics
MH  - Recurrence
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Sialoglycoproteins/*genetics
MH  - Spain/epidemiology
EDAT- 1997/12/31 02:41
MHDA- 2000/06/01 09:00
CRDT- 1997/12/31 02:41
PHST- 1997/12/31 02:41 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1997/12/31 02:41 [entrez]
AID - S0165-5728(97)00153-7 [pii]
AID - 10.1016/s0165-5728(97)00153-7 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1997 Dec;80(1-2):172-8. doi: 10.1016/s0165-5728(97)00153-7.