PMID- 9414018
OWN - NLM
STAT- MEDLINE
DCOM- 19980120
LR  - 20131121
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 28
IP  - 1
DP  - 1998 Jan
TI  - Effects of pharmacologic increases in brain GABA levels on cocaine-induced 
      changes in extracellular dopamine.
PG  - 60-5
AB  - Cocaine-induced increases in extracellular dopamine (DA) concentrations were 
      measured using in vivo microdialysis techniques in the nucleus accumbens (NACC) 
      of freely moving rats. In control animals, cocaine increased extracellular DA 
      concentrations approximately 482% 60 min following administration, returning to 
      baseline values 200 min later. When administered 2 h following an acute dose of 
      gamma-vinyl-GABA (GVG, Vigabatrin), cocaine-induced increases in extracellular DA 
      were reduced to approximately 365% of baseline values. Chronic GVG administration 
      further dose-dependently attenuated the effects of cocaine but did not alter the 
      rate of increase or the rate of return to baseline values. These results indicate 
      that GVG, a drug that increases brain GABA concentrations, is effective in 
      attenuating the effect of cocaine on NACC DA. Taken with our earlier findings, 
      these results support the targeting of brain GABAergic systems as a potentially 
      effective pharmacologic treatment strategy for cocaine addiction.
FAU - Morgan, A E
AU  - Morgan AE
AD  - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA.
FAU - Dewey, S L
AU  - Dewey SL
LA  - eng
GR  - MH-49165/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - GR120KRT6K (Vigabatrin)
RN  - I5Y540LHVR (Cocaine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Dopamine/*metabolism
MH  - Male
MH  - Microdialysis
MH  - Motor Activity/drug effects
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vigabatrin
MH  - gamma-Aminobutyric Acid/analogs & derivatives/*metabolism/pharmacology
EDAT- 1997/12/31 02:43
MHDA- 2000/06/20 09:00
CRDT- 1997/12/31 02:43
PHST- 1997/12/31 02:43 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/12/31 02:43 [entrez]
AID - 10.1002/(SICI)1098-2396(199801)28:1<60::AID-SYN7>3.0.CO;2-A [pii]
AID - 10.1002/(SICI)1098-2396(199801)28:1<60::AID-SYN7>3.0.CO;2-A [doi]
PST - ppublish
SO  - Synapse. 1998 Jan;28(1):60-5. doi: 
      10.1002/(SICI)1098-2396(199801)28:1<60::AID-SYN7>3.0.CO;2-A.