PMID- 9414293
OWN - NLM
STAT- MEDLINE
DCOM- 19980202
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 91
IP  - 1
DP  - 1998 Jan 1
TI  - Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood 
      mononuclear cells and in the U937 cell line.
PG  - 258-65
AB  - Induction of chemokine gene expression from peripheral blood mononuclear cells 
      (PBMCs) stimulated by proinflammatory cytokines plays an important role in both 
      wound repair and response to infectious agents. In the present study, we show 
      that the proinflammatory cytokine interleukin-6 (IL-6) potently induced mRNA 
      expression and secretion of the CC chemokine monocyte chemotactic protein 1 
      (MCP-1) in PBMCs. In addition, because human immunodeficiency virus (HIV) 
      infection in vivo and in vitro has been shown to dysregulate the production of 
      and/or the response to cytokines, PBMCs from both healthy uninfected and 
      HIV-infected individuals were studied for their constitutive and IL-6-induced 
      expression of MCP-1. No substantial differences were observed between the two 
      groups of individuals. In addition, IL-6 upregulated MCP-1 expression in the 
      promonocytic cell line U937 and in its chronically HIV-infected counterpart, U1. 
      In these cell lines, IL-6 selectively induced MCP-1 and not other chemokines, 
      including regulated upon activation normal T cells expressed and secreted 
      (RANTES), macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and 
      IL-8. IL-6 induction of MCP-1 was partially inhibited by hydrocortisone in U1 
      cells. Thus, IL-6 activates PBMCs to secrete MCP-1, a CC chemokine pivotal for 
      monocyte recruitment in tissue and organs in which important inflammatory events 
      occur.
FAU - Biswas, P
AU  - Biswas P
AD  - AIDS Immunopathogenesis Unit, DIBIT, and the Division of Infectious Diseases, San 
      Raffaele Scientific Institute, Milan, Italy.
FAU - Delfanti, F
AU  - Delfanti F
FAU - Bernasconi, S
AU  - Bernasconi S
FAU - Mengozzi, M
AU  - Mengozzi M
FAU - Cota, M
AU  - Cota M
FAU - Polentarutti, N
AU  - Polentarutti N
FAU - Mantovani, A
AU  - Mantovani A
FAU - Lazzarin, A
AU  - Lazzarin A
FAU - Sozzani, S
AU  - Sozzani S
FAU - Poli, G
AU  - Poli G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
RN  - 82115-62-6 (Interferon-gamma)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis/genetics/metabolism
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/metabolism
MH  - Gene Expression Regulation/*drug effects
MH  - Gene Expression Regulation, Leukemic/drug effects
MH  - HIV Infections/blood/pathology
MH  - Humans
MH  - Hydrocortisone/pharmacology
MH  - Interferon-gamma/pharmacology
MH  - Interleukin-6/*pharmacology
MH  - Interleukin-8/biosynthesis/genetics
MH  - Leukocytes, Mononuclear/*drug effects/metabolism
MH  - Lymphoma, Large B-Cell, Diffuse/*pathology
MH  - Macrophage Inflammatory Proteins/biosynthesis/genetics
MH  - Monocytes/*drug effects/metabolism
MH  - Neoplasm Proteins/*biosynthesis/genetics
MH  - Neoplastic Stem Cells/*drug effects/metabolism
MH  - RNA, Messenger/biosynthesis/genetics
MH  - RNA, Neoplasm/biosynthesis/genetics
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
AID - S0006-4971(20)54905-7 [pii]
PST - ppublish
SO  - Blood. 1998 Jan 1;91(1):258-65.