PMID- 9416484
OWN - NLM
STAT- MEDLINE
DCOM- 19980122
LR  - 20190822
IS  - 0309-0167 (Print)
IS  - 0309-0167 (Linking)
VI  - 31
IP  - 5
DP  - 1997 Nov
TI  - Expression of c-Met correlates with grade of malignancy in human astrocytic 
      tumours: an immunohistochemical study.
PG  - 436-43
AB  - AIMS: Recent studies suggest the involvement of hepatocyte growth factor/scatter 
      factor (HGF/SF) in glioma cell invasion and tumour progression. We investigated 
      the distribution and rate of tumour cells that express c-Met protein, which is 
      the cell-surface receptor for HGF/SF, in astrocytic tumours. The type of cells 
      that express c-Met in tumour tissues was also identified. METHODS AND RESULTS: 
      c-Met expression was screened immunohistochemically in a total of 43 astrocytic 
      tumours, including 14 low-grade astrocytomas (A), 13 anaplastic astrocytomas (AA) 
      and 16 glioblastoma multiforme (GBM), c-Met reactivity was demonstrated 
      predominantly in the cytoplasm of tumour cells. Bizarre large tumour cells tended 
      to stain intensely. Higher c-Met expression levels (> or = 2+, more than 25% 
      cells were positive) were noted in 21.4% of (A) vs. 53.8% in (AA) and 87.5% in 
      (GBM) (P < 0.001), indicating a clear relationship between c-Met protein staining 
      and higher grade astrocytic tumours. Moreover, c-Met immunoreactivity was also 
      shown in tumour microvasculature, reactive astrocytes, and neurones in the cortex 
      infiltrated by glioma cells. In 85.7% of cases containing infiltrated cortex, 
      neurones were positive vs. no neurones in non-neoplastic regions (P < 0.002). 
      CONCLUSIONS: This evidence suggests that c-Met expression in the brain could be 
      associated with astrocytoma progression and also reactive process. 
      Immunohistochemical determination of c-Met-expressing cell types helps to 
      understand possible roles of c-Met in tumour tissues.
FAU - Nabeshima, K
AU  - Nabeshima K
AD  - Second Department of Pathology, Miyazaki Medical College, Japan.
FAU - Shimao, Y
AU  - Shimao Y
FAU - Sato, S
AU  - Sato S
FAU - Kataoka, H
AU  - Kataoka H
FAU - Moriyama, T
AU  - Moriyama T
FAU - Kawano, H
AU  - Kawano H
FAU - Wakisaka, S
AU  - Wakisaka S
FAU - Koono, M
AU  - Koono M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Astrocytes/metabolism/pathology
MH  - Astrocytoma/blood supply/*metabolism/pathology
MH  - Brain Neoplasms/blood supply/*metabolism/pathology
MH  - Cerebral Cortex/metabolism/pathology
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Microcirculation/metabolism/pathology
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Neurons/metabolism/pathology
MH  - Proto-Oncogene Proteins c-met/*biosynthesis
EDAT- 1998/01/07 00:00
MHDA- 1998/01/07 00:01
CRDT- 1998/01/07 00:00
PHST- 1998/01/07 00:00 [pubmed]
PHST- 1998/01/07 00:01 [medline]
PHST- 1998/01/07 00:00 [entrez]
AID - 10.1046/j.1365-2559.1997.3010889.x [doi]
PST - ppublish
SO  - Histopathology. 1997 Nov;31(5):436-43. doi: 10.1046/j.1365-2559.1997.3010889.x.