PMID- 9416774
OWN - NLM
STAT- MEDLINE
DCOM- 19980120
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 61
IP  - 26
DP  - 1997
TI  - Brain histamine mediates the bombesin-induced central activation of 
      sympatho-adrenomedullary outflow.
PG  - 2521-8
AB  - Intracerebroventricular (i.c.v.) administration of bombesin (0.3 nmol) increased 
      plasma levels of both adrenaline and noradrenaline in urethane anesthetized rats. 
      These bombesin-induced increases were inhibited by i.c.v. pretreatment with 
      pyrilamine, an H1-receptor antagonist. Ranitidine, an H2-receptor antagonist also 
      inhibited the increase of adrenaline, however, its effective dose was much larger 
      than that of pyrilamine. Furthermore, the bombesin-induced increase of 
      noradrenaline was not effectively inhibited by ranitidine. In the next series, 
      turnover of histamine was assessed by measuring accumulation of 
      tele-methylhistamine (t-MH), a major metabolite of brain histamine. I.c.v. 
      administration of bombesin (0.3-3 nmol) increased turnover of hypothalamic 
      histamine, while its intravenous administration was without effect. The present 
      results suggest that the bombesin-induced central activation of 
      sympatho-adrenomedullary outflow is probably, at least in part, mediated through 
      brain histaminergic neurons.
FAU - Okuma, Y
AU  - Okuma Y
AD  - Department of Pharmacology, Kochi Medical School, Japan.
FAU - Yokotani, K
AU  - Yokotani K
FAU - Murakami, Y
AU  - Murakami Y
FAU - Osumi, Y
AU  - Osumi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 820484N8I3 (Histamine)
RN  - 884KT10YB7 (Ranitidine)
RN  - 9MV14S8G3E (Pargyline)
RN  - HPE317O9TL (Pyrilamine)
RN  - PX9AZU7QPK (Bombesin)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenal Medulla/*drug effects/physiology
MH  - Animals
MH  - Bombesin/administration & dosage/*pharmacology
MH  - Brain/*metabolism
MH  - Epinephrine/blood
MH  - Histamine/*physiology
MH  - Histamine H1 Antagonists/pharmacology
MH  - Histamine H2 Antagonists/pharmacology
MH  - Hypothalamus/drug effects/metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Norepinephrine/blood
MH  - Pargyline/pharmacology
MH  - Pyrilamine/pharmacology
MH  - Ranitidine/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Sympathetic Nervous System/*drug effects/physiology
EDAT- 1997/01/01 00:00
MHDA- 1998/01/07 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/01/07 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0024320597010060 [pii]
AID - 10.1016/s0024-3205(97)01006-0 [doi]
PST - ppublish
SO  - Life Sci. 1997;61(26):2521-8. doi: 10.1016/s0024-3205(97)01006-0.