PMID- 9421437
OWN - NLM
STAT- MEDLINE
DCOM- 19980115
LR  - 20181201
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 139
IP  - 1
DP  - 1998 Jan
TI  - Centrally administered parathyroid hormone (PTH)-related protein(1-34) but not 
      PTH(1-34) stimulates arginine-vasopressin secretion and its messenger ribonucleic 
      acid expression in supraoptic nucleus of the conscious rats.
PG  - 383-8
AB  - It has been suggested that PTH-related protein (PTHrP) is an endogenous modulator 
      of cardiovascular systems. We have reported that PTHrP(1-34), but not PTH(1-34), 
      causes the release of arginine-vasopressin (AVP) from the supraoptic nucleus 
      (SON) of the hypothalamus in vitro through a novel receptor distinct from the 
      PTH/PTHrP receptors (type I or type II) described previously. In this study, we 
      have investigated the in vivo effects of PTHrP(1-34) on AVP secretion and its, 
      messenger RNA (mRNA) expression in the SON in conscious rats. 
      Intracerebroventricular (i.c.v.) administration of PTHrP(1-34) resulted in an 
      increase in plasma AVP concentration in a dose-dependent manner (0-400 pmol/rat). 
      The maximal effect was obtained at 15 min after i.c.v. administration of 
      PTHrP(1-34). Neither PTHrP(7-34) nor PTH(1-34) had any effect on plasma AVP 
      levels. PTHrP(1-34)-induced AVP secretion was antagonized by pretreatment with 
      PTHrP(7-34) but not by that with PTH(1-34). In addition, in situ hybridization 
      study revealed that AVP mRNA expression in the SON and paraventricular nucleus 
      was significantly increased 30 min after i.c.v. administration of PTHrP(1-34) and 
      reached a maximum at 180 min. Furthermore, in Northern blot analyses, AVP mRNA 
      expression in the SON was increased to approximately a 2-fold of basal level by 
      PTHrP(1-34). On the other hand, neither PTHrP(7-34) or PTH(1-34) had any effect 
      on the mRNA expression. The PTHrP(1-34)-stimulated AVP mRNA expression was 
      eliminated by pretreatment with PTHrP(7-34) but not with PTH(1-34). These results 
      suggest that, in the central nervous system, PTHrP(1-34) is involved in AVP 
      secretion through a novel receptor distinct from the PTH/PTHrP receptors reported 
      previously, playing a role in the body water and electrolyte homeostasis.
FAU - Yamamoto, S
AU  - Yamamoto S
AD  - First Department of Internal Medicine, School of Medicine, University of 
      Occupational and Environmental Health, Kitakyushu, Japan.
FAU - Morimoto, I
AU  - Morimoto I
FAU - Zeki, K
AU  - Zeki K
FAU - Ueta, Y
AU  - Ueta Y
FAU - Yamashita, H
AU  - Yamashita H
FAU - Kannan, H
AU  - Kannan H
FAU - Eto, S
AU  - Eto S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Parathyroid Hormone-Related Protein)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Parathyroid Hormone, Type 1)
RN  - 0 (Receptors, Parathyroid Hormone)
RN  - 10T9CSU89I (Teriparatide)
RN  - 113-79-1 (Arginine Vasopressin)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/genetics/*metabolism
MH  - Blotting, Northern
MH  - In Situ Hybridization
MH  - Injections, Intraventricular
MH  - Male
MH  - Parathyroid Hormone-Related Protein
MH  - Proteins/administration & dosage/*pharmacology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Parathyroid Hormone, Type 1
MH  - Receptors, Parathyroid Hormone/physiology
MH  - Supraoptic Nucleus/*metabolism
MH  - Teriparatide/administration & dosage/*pharmacology
EDAT- 1998/01/08 00:00
MHDA- 1998/01/08 00:01
CRDT- 1998/01/08 00:00
PHST- 1998/01/08 00:00 [pubmed]
PHST- 1998/01/08 00:01 [medline]
PHST- 1998/01/08 00:00 [entrez]
AID - 10.1210/endo.139.1.5697 [doi]
PST - ppublish
SO  - Endocrinology. 1998 Jan;139(1):383-8. doi: 10.1210/endo.139.1.5697.