PMID- 9422320
OWN - NLM
STAT- MEDLINE
DCOM- 19980122
LR  - 20190822
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 22
IP  - 1
DP  - 1998 Jan
TI  - Sclerosing stromal tumor of the ovary: a clinicopathologic, immunohistochemical, 
      ultrastructural, and cytogenetic analysis with special reference to its 
      vasculature.
PG  - 83-92
AB  - Sclerosing stromal tumor (SST) is a rare ovarian neoplasm occurring predominantly 
      in young women and is histologically characterized by cellular heterogeneity, 
      prominent vasculature, and a pseudolobular appearance composed of cellular and 
      hypocellular areas. In the current study, three cases of SST were 
      ultrastructurally examined and the tumors were found to be composed of several 
      kinds of cells, i.e., luteinized thecalike cells, spindle-shaped fibroblastic 
      cells, and primitive mesenchymal cells. These findings thus supported the ovarian 
      stromal origin of SST. Twelve cases of SST also were analyzed 
      immunohistochemically and demonstrated an expression of vascular permeability 
      factor/vascular endothelial growth factor (VPF/VEGF) in the luteinized thecalike 
      cells and its receptor, fms-like tyrosine kinase 1 (flt-1), in capillary to 
      medium-sized blood vessels. Reverse transcription-polymerase chain reaction 
      (RT-PCR) also showed an expression of VPF/VEGF messenger RNA in SSTs. 
      Accordingly, the characteristic vasculature and edema of SSTs were considered to 
      be associated with the expression of VPF/VEGF. In addition, a fluorescence in 
      situ hybridization (FISH) analysis also showed cells with three copy number of 
      chromosome 12 in 13-21% of all examined SST cells, which suggested the presence 
      of chromosome 12 trisomy in SSTs as well as in other ovarian stromal tumors.
FAU - Kawauchi, S
AU  - Kawauchi S
AD  - Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, 
      Japan.
FAU - Tsuji, T
AU  - Tsuji T
FAU - Kaku, T
AU  - Kaku T
FAU - Kamura, T
AU  - Kamura T
FAU - Nakano, H
AU  - Nakano H
FAU - Tsuneyoshi, M
AU  - Tsuneyoshi M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (DNA Primers)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Capillaries/metabolism
MH  - Chromosomes, Human, Pair 12
MH  - Cytogenetics
MH  - DNA Primers/chemistry
MH  - Endothelial Growth Factors/genetics/metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphokines/genetics/metabolism
MH  - Middle Aged
MH  - Ovarian Neoplasms/blood supply/metabolism/*pathology/ultrastructure
MH  - Polymerase Chain Reaction
MH  - Proto-Oncogene Proteins/genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptor Protein-Tyrosine Kinases/genetics/metabolism
MH  - Sex Cord-Gonadal Stromal Tumors/blood supply/metabolism/*pathology/ultrastructure
MH  - Trisomy
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factor Receptor-1
MH  - Vascular Endothelial Growth Factors
EDAT- 1998/01/09 00:00
MHDA- 1998/01/09 00:01
CRDT- 1998/01/09 00:00
PHST- 1998/01/09 00:00 [pubmed]
PHST- 1998/01/09 00:01 [medline]
PHST- 1998/01/09 00:00 [entrez]
AID - 10.1097/00000478-199801000-00011 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 1998 Jan;22(1):83-92. doi: 10.1097/00000478-199801000-00011.