PMID- 9422517
OWN - NLM
STAT- MEDLINE
DCOM- 19980130
LR  - 20181113
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 152
IP  - 1
DP  - 1998 Jan
TI  - Consistent copy number gain in chromosome 12 in primary diffuse large cell 
      lymphomas of the stomach.
PG  - 11-6
AB  - Fifteen cases of high grade primary gastric non-Hodgkin's lymphomas were studied 
      using comparative genomic hybridization (CGH) and/or fluorescence in situ 
      hybridization (FISH) techniques. A total of 10 cases of diffuse large cell 
      lymphoma (DLCL) with no histologically identifiable or previous history of low 
      grade mucosa-associated lymphoid tissue (MALT) lymphoma components were examined, 
      four by CGH and validated by FISH, and the remaining six by FISH alone. All 10 
      tumors showed gains in chromosome 12. Other recurring CGH findings in DLCL 
      included copy number gains of 1q and deletions of 6q. Five cases of high grade 
      tumors with low grade MALT components (HGM) were also examined, three by CGH and 
      validated by FISH and two by FISH only. Only one in five HGM showed gains of 
      chromosome 12. Other recurring CGH findings in HGM included +7q and +11q. We 
      conclude that high grade gastric lymphomas of DLCL type were associated with 
      gains in chromosome 12. The change was much less frequent (P < 0.01) in the HGM 
      type, which had a percentage similar to that observed in previously reported 
      cytogenetics/FISH studies on low grade MALT lymphomas. Our findings suggested 
      that many DLCL were not derived from transformation of low grade MALT lymphomas.
FAU - Chan, W Y
AU  - Chan WY
AD  - Department of Anatomical & Cellular Pathology, Chinese University of Hong Kong, 
      Shatin, N.T., Hong Kong. wingchan@cuhk.edu.hk
FAU - Wong, N
AU  - Wong N
FAU - Chan, A B
AU  - Chan AB
FAU - Chow, J H
AU  - Chow JH
FAU - Lee, J C
AU  - Lee JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosomes, Human, Pair 12
MH  - Female
MH  - Gene Deletion
MH  - *Gene Dosage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - Stomach Neoplasms/*genetics
PMC - PMC1858110
EDAT- 1998/01/09 00:00
MHDA- 1998/01/09 00:01
PMCR- 1998/07/01
CRDT- 1998/01/09 00:00
PHST- 1998/01/09 00:00 [pubmed]
PHST- 1998/01/09 00:01 [medline]
PHST- 1998/01/09 00:00 [entrez]
PHST- 1998/07/01 00:00 [pmc-release]
PST - ppublish
SO  - Am J Pathol. 1998 Jan;152(1):11-6.