PMID- 9424321 OWN - NLM STAT- MEDLINE DCOM- 19980102 LR - 20061115 IS - 1426-9686 (Print) IS - 1426-9686 (Linking) VI - 2 IP - 12 DP - 1997 Jun TI - [Biology and clinical pharmacology of tumor necrosis factor alpha]. PG - 355-8 AB - Tumor necrosis factor-alpha (TNF-alpha) or cachectin is a cytokine with multiple biological actions. TNF-alpha has been implicated as an important mediator of inflammation and as a key element of immune effector cell regulation. This macrophage product has been biochemically characterized and its protein structure defined by molecular cloning of the TNF gene. The availability of human TNF-alpha has allowed the initiation of clinical investigations into the antitumor properties of this factor. FAU - Maranda, E AU - Maranda E FAU - Robak, T AU - Robak T LA - pol PT - Editorial PT - English Abstract TT - Biologia i farmakologia kliniczna czynnika martwicy nowotworow alpha. PL - Poland TA - Pol Merkur Lekarski JT - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JID - 9705469 RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Cloning, Molecular MH - Humans MH - Tumor Necrosis Factor-alpha/*pharmacology/*physiology EDAT- 1997/06/01 00:00 MHDA- 1998/01/10 00:01 CRDT- 1997/06/01 00:00 PHST- 1997/06/01 00:00 [pubmed] PHST- 1998/01/10 00:01 [medline] PHST- 1997/06/01 00:00 [entrez] PST - ppublish SO - Pol Merkur Lekarski. 1997 Jun;2(12):355-8.