PMID- 9425184
OWN - NLM
STAT- MEDLINE
DCOM- 19980218
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 79
IP  - 1
DP  - 1998 Jan
TI  - Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient 
      mice.
PG  - 137-42
AB  - We studied synaptic transmission in the granule cells in the olfactory bulb of 
      the homozygous Fyn (a nonreceptor type tyrosine kinase)-deficient (fynz/fynz) and 
      heterozygous Fyn-deficient (+/fynz) mice by using slice preparations from the 
      olfactory bulb. Stimulation to the lateral olfactory tract and/or centrifugal 
      fibers to the olfactory bulb evoked field excitatory postsynaptic potentials 
      (fEPSPs) in the granule cells. In +/fynz mice, fEPSPs were augmented by 
      bicuculline, a gamma-aminobutyric acid (GABAA) antagonist and picrotoxin, whereas 
      fEPSPs in fynz/fynz mice were much less sensitive to bicuculline and picrotoxin. 
      Application of D-2-amino-5-phosphonopentanoic acid had no effect but 
      6-cyano-7-nitroquinoxaline-2,3-dione produced almost complete block of fEPSPs in 
      both +/fynz mice and fynz/fynz mice. 
      (1S,3R)-1-aminocyclo-pentane-1.3-dicarboxylate, an agonist of metabotropic 
      glutamate receptors caused a similar depression of fEPSPs in both +/fynz and 
      fynz/fynz mice. In +/fynz mice tetanic stimulation to the lateral olfactory tract 
      and/or centrifugal fibers induced N-methyl-D-aspartate (NMDA)-dependent long-term 
      potentiation (LTP) of fEPSPs, whereas LTP was impaired in fynz/fynz mice. Our 
      results demonstrate altered functions of GABAA and NMDA receptors in the 
      olfactory system of Fyn-deficient mice.
FAU - Kitazawa, H
AU  - Kitazawa H
AD  - Department of Physiology, Jichi Medical School, Tochigi 329-04, Japan.
FAU - Yagi, T
AU  - Yagi T
FAU - Miyakawa, T
AU  - Miyakawa T
FAU - Niki, H
AU  - Niki H
FAU - Kawai, N
AU  - Kawai N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Glutamate)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - 124-87-8 (Picrotoxin)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Fyn protein, mouse)
RN  - EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Crosses, Genetic
MH  - Cycloleucine/analogs & derivatives/pharmacology
MH  - Electric Stimulation
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/*physiology
MH  - GABA-A Receptor Antagonists
MH  - Heterozygote
MH  - In Vitro Techniques
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Mice, Knockout
MH  - Neurons/cytology/drug effects/*physiology
MH  - Neuroprotective Agents/pharmacology
MH  - Olfactory Bulb/cytology/drug effects/*physiology
MH  - Picrotoxin/pharmacology
MH  - Protein-Tyrosine Kinases/deficiency
MH  - Proto-Oncogene Proteins/*deficiency/genetics/physiology
MH  - Proto-Oncogene Proteins c-fyn
MH  - Receptors, Glutamate/physiology
MH  - Synaptic Transmission/*physiology
EDAT- 1998/02/21 00:00
MHDA- 1998/02/21 00:01
CRDT- 1998/02/21 00:00
PHST- 1998/02/21 00:00 [pubmed]
PHST- 1998/02/21 00:01 [medline]
PHST- 1998/02/21 00:00 [entrez]
AID - 10.1152/jn.1998.79.1.137 [doi]
PST - ppublish
SO  - J Neurophysiol. 1998 Jan;79(1):137-42. doi: 10.1152/jn.1998.79.1.137.