PMID- 9428305
OWN - NLM
STAT- MEDLINE
DCOM- 19980204
LR  - 20071114
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 18
IP  - 1
DP  - 1998 Jan
TI  - Circulating antibody against tumor necrosis factor-alpha protects rat brain from 
      reperfusion injury.
PG  - 52-8
AB  - The role of tumor necrosis factor-alpha (TNF alpha) in brain injury is 
      controversial. We studied the effect of anti-TNF-alpha antibody in a rat model of 
      reversible middle cerebral artery occlusion. During focal ischemia and early 
      reperfusion, TNF-alpha was rapidly and transiently released into circulation. 
      Pretreatment with intravenous anti-TNF-alpha antibody reduced cortical (71%, P < 
      0.015) and subcortical (58%, P < 0.007) injury, enhanced the cerebral blood flow 
      during reperfusion, and improved the neurologic outcome. This further supports 
      the contention that TNF-alpha is a deleterious cytokine in stroke, whereas 
      circulating antibody against TNF-alpha may protect brain from reperfusion injury.
FAU - Lavine, S D
AU  - Lavine SD
AD  - Department of Neurological Surgery, Children's Hospital, Los Angeles, California, 
      USA.
FAU - Hofman, F M
AU  - Hofman FM
FAU - Zlokovic, B V
AU  - Zlokovic BV
LA  - eng
GR  - NS31945/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Antibodies)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Antibodies/*administration & dosage/blood
MH  - Brain/*blood supply
MH  - Brain Ischemia/*immunology/prevention & control
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/*immunology/prevention & control
MH  - Tumor Necrosis Factor-alpha/*immunology
EDAT- 1998/01/15 00:00
MHDA- 1998/01/15 00:01
CRDT- 1998/01/15 00:00
PHST- 1998/01/15 00:00 [pubmed]
PHST- 1998/01/15 00:01 [medline]
PHST- 1998/01/15 00:00 [entrez]
AID - 10.1097/00004647-199801000-00005 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 1998 Jan;18(1):52-8. doi: 
      10.1097/00004647-199801000-00005.