PMID- 9430772
OWN - NLM
STAT- MEDLINE
DCOM- 19980130
LR  - 20190921
IS  - 0140-7783 (Print)
IS  - 0140-7783 (Linking)
VI  - 20
IP  - 6
DP  - 1997 Dec
TI  - Pharmacokinetics of enrofloxacin in newborn and one-week-old calves.
PG  - 479-82
AB  - The pharmacokinetic behaviour of enrofloxacin was compared in four one-day-old 
      and four one-week-old calves in order to find out if there were any age-related 
      differences. Mean volume of distribution (Vd(ss)) and clearance (Cl) were 
      significantly smaller in newborn calves: Vd(ss) was 1.8 and 2.3 L/kg, while 
      clearance was 0.19 and 0.39 L/kg.h in newborn and one-week-old calves, 
      respectively. Mean elimination half-life (t1/2 beta) did not differ significantly 
      in newborn and in one-week-old calves: mean t1/2 beta was 6.6 h and 4.9 h, 
      respectively. Enrofloxacin was metabolized to ciprofloxacin both by newborn and 
      one-week-old calves, but the maximum concentration (Cmax) of ciprofloxacin was 
      lower and the time when maximum concentration was reached (tmax) later in newborn 
      calves. We conclude that the dosage of enrofloxacin should be adjusted according 
      to age when administered to very young calves.
FAU - Kaartinen, L
AU  - Kaartinen L
AD  - University of Helsinki, Faculty of Veterinary Medicine, Department of Clinical 
      Veterinary Sciences, Finland. liisa.kaartinen@nam.fi
FAU - Pyorala, S
AU  - Pyorala S
FAU - Moilanen, M
AU  - Moilanen M
FAU - Raisanen, S
AU  - Raisanen S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Quinolones)
RN  - 3DX3XEK1BN (Enrofloxacin)
RN  - 5E8K9I0O4U (Ciprofloxacin)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Animals, Newborn/*metabolism
MH  - Anti-Infective Agents/*pharmacokinetics
MH  - Area Under Curve
MH  - Cattle
MH  - Chromatography, High Pressure Liquid
MH  - Ciprofloxacin/metabolism
MH  - Enrofloxacin
MH  - *Fluoroquinolones
MH  - Half-Life
MH  - Injections, Intravenous
MH  - Metabolic Clearance Rate
MH  - Quinolones/*pharmacokinetics
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
AID - 10.1046/j.1365-2885.1997.00100.x [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 1997 Dec;20(6):479-82. doi: 
      10.1046/j.1365-2885.1997.00100.x.