PMID- 9430790
OWN - NLM
STAT- MEDLINE
DCOM- 19980204
LR  - 20191102
IS  - 1350-1925 (Print)
IS  - 1350-1925 (Linking)
VI  - 9
IP  - 4
DP  - 1997 Dec
TI  - Central regulation of gastric emptying of solid nutrient meals by corticotropin 
      releasing factor.
PG  - 221-9
AB  - Central regulation of gastric emptying of a solid nutrient meal and spatial and 
      temporal parameters of gastro-pyloro-duodenal contractions by 
      corticotropin-releasing factor (CRF) were investigated in conscious dogs. 
      Intracerebroventricular (i.c.v.) infusion of CRF at 0.033 nmol kg-1 min-1 for 15 
      min in a volume of 0.2 mL significantly delayed the total gastric emptying time 
      of the meal. I.c.v infusion of CRF also increased the mean frequency of proximal 
      duodenal contractions and decreased the percentage of distally propagating 
      contractions in the whole duodenum. The remaining parameters of pyloric and 
      duodenal contractions were not affected. A prior i.c.v. infusion of I-helical 
      CRF9-41 (0.166 nmol kg-1 min-1 for 15 min in a volume of 0.2 mL) blocked the 
      central effects of CRF on gastric emptying time and the duodenal contractions. 
      Central infusion of CRF had no significant effect on the lag phase of gastric 
      emptying. Bilateral truncal vagotomy significantly delayed the gastric emptying 
      time of the solid nutrient meal. However, after vagotomy, i.c.v. infusion of CRF 
      had no effect on gastric emptying time or the spatial and temporal parameters of 
      gastro-pyloro-duodenal contractions. In conclusion, CRF, the mediator of stress 
      response, delays the total gastric emptying time of solid nutrient meals. The 
      delay in gastric emptying may not be due to a change in the spatial and temporal 
      parameters of gastric or pyloric contractions, but mainly due to changes in the 
      parameters of duodenal contractions. The central effects of CRF on gastric 
      emptying and duodenal contractions may be mediated by the vagus nerves.
FAU - Lee, C
AU  - Lee C
AD  - Department of Surgery, Medical College of Wisconsin, Milwaukee, USA.
FAU - Sarna, S K
AU  - Sarna SK
LA  - eng
GR  - DK32346/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Corticotropin-Releasing Hormone/administration & dosage/*pharmacology
MH  - Dogs
MH  - Duodenum/drug effects/physiology
MH  - Eating
MH  - Female
MH  - Gastric Emptying/*drug effects/physiology
MH  - Gastrointestinal Motility/*drug effects/physiology
MH  - Infusions, Parenteral
MH  - Male
MH  - Muscle Contraction/drug effects/physiology
MH  - Muscle, Smooth/drug effects/physiology
MH  - Pylorus/drug effects/physiology
MH  - Stomach/drug effects/physiology
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
AID - 10.1046/j.1365-2982.1997.d01-58.x [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 1997 Dec;9(4):221-9. doi: 
      10.1046/j.1365-2982.1997.d01-58.x.