PMID- 9435804
OWN - NLM
STAT- MEDLINE
DCOM- 19980128
LR  - 20091111
IS  - 0007-4551 (Print)
IS  - 0007-4551 (Linking)
VI  - 84
IP  - 10
DP  - 1997 Oct
TI  - [Identification of the gene associated with type 1 multiple endocrine neoplasia 
      (NEM 1) susceptibility: a new pathway in the pathogenesis of neuro-endocrine 
      tumors].
PG  - 993-5
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant inherited 
      disorder characterized by tumors of the parathyroids, endocrine pancreas, 
      anterior pituitary, thymic, bronchic and digestive neuro-endocrine tissues and 
      adrenal glands. The MEN1 gene has been recently cloned by two independent groups. 
      The function of the protein encoded by the MEN1 gene is unknown until now. 
      Germline mutations associated to the diseases in MEN1 families are distributed 
      throughout all the open reading frame, suggesting the absence of founder effect. 
      No consistent genotype-phenotype correlations have been yet recognized. Further 
      studies on the functional domains of the MEN1 encoded protein could be useful to 
      relate clinical expression of the disease with each type of mutation.
FAU - Calender, A
AU  - Calender A
AD  - Unite de genetique, Pavillon E, Hopital Edouard-Herriot, Lyon, France.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'identification du gene associe a la predisposition aux neoplasies 
      endocriniennes multiples de type 1 (NEM 1): une nouvelle voie de recherche dans 
      la physiopathogenie des tumeurs neuro-endocrines.
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Disease Susceptibility
MH  - Gene Expression
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutagenesis
MH  - Neoplasm Proteins/*genetics
EDAT- 1998/01/22 00:00
MHDA- 1998/01/22 00:01
CRDT- 1998/01/22 00:00
PHST- 1998/01/22 00:00 [pubmed]
PHST- 1998/01/22 00:01 [medline]
PHST- 1998/01/22 00:00 [entrez]
PST - ppublish
SO  - Bull Cancer. 1997 Oct;84(10):993-5.