PMID- 9437316
OWN - NLM
STAT- MEDLINE
DCOM- 19980129
LR  - 20220321
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 125
IP  - 1
DP  - 1998 Jan
TI  - Presumed macular choroidal watershed vascular filling, choroidal 
      neovascularization, and systemic vascular disease in patients with age-related 
      macular degeneration.
PG  - 71-80
AB  - PURPOSE: To investigate the possible association of presumed macular choroidal 
      watershed vascular filling (PMWF), choroidal neovascularization, and systemic 
      vascular disease in patients with age-related macular degeneration. METHODS: In a 
      retrospective study, we evaluated 74 randomly selected indocyanine green 
      videoangiograms of 74 patients with age-related macular degeneration. We also 
      reviewed the charts of 20 randomly selected, age-matched control patients without 
      age-related macular degeneration, initially referred for uniocular conditions, 
      and subsequently performed indocyanine green videoangiography on their normal 
      fellow eyes. We evaluated these videoangiograms for the presence of PMWF, 
      manifesting as characteristic early choroidal hypofluorescence and its relation 
      to choroidal neovascularization when present. Additionally, the incidence of 
      hypertension, coronary artery disease, peripheral vascular disease, and diabetes 
      mellitus was determined. RESULTS: Forty-one (55.4%) of 74 patients with 
      age-related macular degeneration vs three (15.0%) of 20 normal control patients 
      exhibited PMWF on indocyanine green videoangiography (P = .0014). Of the 61 
      patients with age-related macular degeneration and choroidal neovascularization, 
      36 (59.0%) exhibited PMWF on videoangiography. Associated choroidal 
      neovascularization arose from the PMWF zone in 33 (91.7%) of these cases. 
      Hypertension was observed in 24 (58.5%) of 41 patients with age-related macular 
      degeneration and PMWF vs nine (27.3%) of 33 patients with age-related macular 
      degeneration who did not exhibit PMWF (P = .007). CONCLUSIONS: An increased 
      incidence of PMWF occurs in patients with age-related macular degeneration with a 
      possible predisposition for the development of associated choroidal 
      neovascularization. Additionally, PMWF may be accentuated by associated 
      hypertensive choroidal microvascular insult.
FAU - Ross, R D
AU  - Ross RD
AD  - Department of Ophthalmology, Touro Infirmary, New Orleans, Louisiana, USA.
FAU - Barofsky, J M
AU  - Barofsky JM
FAU - Cohen, G
AU  - Cohen G
FAU - Baber, W B
AU  - Baber WB
FAU - Palao, S W
AU  - Palao SW
FAU - Gitter, K A
AU  - Gitter KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
CIN - Am J Ophthalmol. 1998 Jul;126(1):153-5. PMID: 9683172
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*blood supply/pathology
MH  - Coloring Agents
MH  - Female
MH  - Fluorescein Angiography
MH  - Fundus Oculi
MH  - Humans
MH  - Incidence
MH  - Indocyanine Green
MH  - Macula Lutea/*blood supply/pathology
MH  - Macular Degeneration/*complications/pathology
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*complications/pathology
MH  - Random Allocation
MH  - Retrospective Studies
MH  - Vascular Diseases/*complications/pathology
EDAT- 1998/01/23 00:00
MHDA- 1998/01/23 00:01
CRDT- 1998/01/23 00:00
PHST- 1998/01/23 00:00 [pubmed]
PHST- 1998/01/23 00:01 [medline]
PHST- 1998/01/23 00:00 [entrez]
AID - S0002-9394(99)80237-2 [pii]
AID - 10.1016/s0002-9394(99)80237-2 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 1998 Jan;125(1):71-80. doi: 10.1016/s0002-9394(99)80237-2.