PMID- 9437410
OWN - NLM
STAT- MEDLINE
DCOM- 19980203
LR  - 20221207
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 242
IP  - 6
DP  - 1997 Dec
TI  - No difference in blood thiamine diphosphate levels between Swedish Caucasian 
      patients with congestive heart failure treated with furosemide and patients 
      without heart failure.
PG  - 491-5
AB  - OBJECTIVES: To determine whether furosemide treatment in congestive heart failure 
      (CHF) patients is associated with thiamine deficiency. DESIGN: Patients without 
      heart failure and without diuretic treatment were included to compare with 
      patients with CHF belonging to New York Heart Association (NYHA) functional class 
      II and III-IV, respectively, and receiving furosemide therapy. SETTING: All 
      patients were recruited from the emergency ward of the cardiology section. 
      Huddinge University Hospital, where they were admitted due to CHF or acute 
      myocardial infarction. SUBJECTS: Ninety-nine patients were included from whom a 
      blood sample was taken, as well as routine admission blood samples for the 
      analysis of thiamine diphosphate (TPP) concentrations. Patients taking vitamin 
      preparations were excluded. MAIN OUTCOME MEASURES: Blood TPP concentrations were 
      measured by high performance liquid chromatography (HPLC) and compared between 
      the patient groups by the use of ANOVA. RESULTS: No significant difference was 
      found between the groups in blood TPP concentrations. CONCLUSIONS: Thiamine 
      deficiency may not be a complication of furosemide treatment in the studied 
      Swedish patient population.
FAU - Yue, Q Y
AU  - Yue QY
AD  - Department of Clinical Pharmacology, Huddinge University Hospital, Sweden.
FAU - Beermann, B
AU  - Beermann B
FAU - Lindstrom, B
AU  - Lindstrom B
FAU - Nyquist, O
AU  - Nyquist O
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Diuretics)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - Q57971654Y (Thiamine Pyrophosphate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromatography, High Pressure Liquid
MH  - Diuretics/*adverse effects/therapeutic use
MH  - Female
MH  - Furosemide/*adverse effects/therapeutic use
MH  - Heart Failure/*blood/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sweden
MH  - Thiamine Pyrophosphate/*blood/deficiency
MH  - *White People
EDAT- 1998/01/23 00:00
MHDA- 1998/01/23 00:01
CRDT- 1998/01/23 00:00
PHST- 1998/01/23 00:00 [pubmed]
PHST- 1998/01/23 00:01 [medline]
PHST- 1998/01/23 00:00 [entrez]
AID - 10.1111/j.1365-2796.1997.tb00022.x [doi]
PST - ppublish
SO  - J Intern Med. 1997 Dec;242(6):491-5. doi: 10.1111/j.1365-2796.1997.tb00022.x.