PMID- 9439676
OWN - NLM
STAT- MEDLINE
DCOM- 19980206
LR  - 20190512
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 88
IP  - 11
DP  - 1997 Nov
TI  - Germline mutations of the MEN1 gene in Japanese kindred with multiple endocrine 
      neoplasia type 1.
PG  - 1029-32
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant familial 
      cancer syndrome. The responsible gene MEN1 has recently been isolated, and its 
      germline mutations have been identified in affected individuals in the United 
      States, Canada and Europe. We screened for MEN1 mutations by direct nucleotide 
      sequencing of all protein-coding regions, and identified five distinct germline 
      mutations in five among six Japanese kindreds with familial MEN1 or familial 
      hyperparathyroidism. The mutations were dispersed across the gene. These findings 
      suggest that, because of the absence of an obvious founder effect, the entire 
      MEN1 gene region should be examined for germline mutations in the probands of 
      MEN1 and related syndromes in Japanese families.
FAU - Shimizu, S
AU  - Shimizu S
AD  - Growth Factor Division, National Cancer Center Research Institute, Tokyo.
FAU - Tsukada, T
AU  - Tsukada T
FAU - Futami, H
AU  - Futami H
FAU - Ui, K
AU  - Ui K
FAU - Kameya, T
AU  - Kameya T
FAU - Kawanaka, M
AU  - Kawanaka M
FAU - Uchiyama, S
AU  - Uchiyama S
FAU - Aoki, A
AU  - Aoki A
FAU - Yasuda, H
AU  - Yasuda H
FAU - Kawano, S
AU  - Kawano S
FAU - Ito, Y
AU  - Ito Y
FAU - Kanbe, M
AU  - Kanbe M
FAU - Obara, T
AU  - Obara T
FAU - Yamaguchi, K
AU  - Yamaguchi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - DNA, Neoplasm/analysis/genetics
MH  - Family Health
MH  - *Germ-Line Mutation
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Polymerase Chain Reaction
PMC - PMC5921317
EDAT- 1998/01/24 00:00
MHDA- 1998/01/24 00:01
PMCR- 1997/11/01
CRDT- 1998/01/24 00:00
PHST- 1998/01/24 00:00 [pubmed]
PHST- 1998/01/24 00:01 [medline]
PHST- 1998/01/24 00:00 [entrez]
PHST- 1997/11/01 00:00 [pmc-release]
AID - S0910505097800920 [pii]
AID - CAE1029 [pii]
AID - 10.1111/j.1349-7006.1997.tb00325.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1997 Nov;88(11):1029-32. doi: 
      10.1111/j.1349-7006.1997.tb00325.x.