PMID- 9439806
OWN - NLM
STAT- MEDLINE
DCOM- 19980224
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 776
IP  - 1-2
DP  - 1997 Nov 21
TI  - P/Q-type Ca2+ channel blocker omega-agatoxin IVA protects against brain injury 
      after focal ischemia in rats.
PG  - 140-5
AB  - Recently, P/Q-type Ca2+ channels have been shown to be involved in 
      neurotransmission in the central nervous system in mammals. We evaluated the 
      effects of the P/Q-type Ca2+ channel blocker omega-agatoxin IVA (omega-Aga-IVA) 
      on brain edema formation and infarct size determined after 24 h of reperfusion 
      following 1 h of middle cerebral artery (MCA) occlusion in rats. 
      Intracerebroventricular (i.c.v.) treatment with omega-Aga-IVA significantly 
      attenuated the postischemic increase of brain water content. omega-Aga-IVA also 
      significantly reduced the size of the infarct area determined by 
      triphenyltetrazolium chloride staining after 24 h of reperfusion. omega-Aga-IVA 
      (30 pmol, i.c.v.), which exhibited a neuroprotective effect, had no significant 
      effect on the magnitude of intra- and postischemic brain temperature when 
      compared with vehicle-treated rats. This indicates that the postischemic 
      neuroprotective effect of omega-Aga-IVA is produced by a direct and not an 
      indirect effect via hypothermia. These results suggest that P/Q-type Ca2+ 
      channels may be involved in the development of focal ischemic brain injury and 
      that blockers of these channels may be therapeutically useful against ischemic 
      injury.
FAU - Asakura, K
AU  - Asakura K
AD  - Discovery Research Laboratories II, Shionogi and Co. Ltd., Osaka, Japan.
FAU - Matsuo, Y
AU  - Matsuo Y
FAU - Kanemasa, T
AU  - Kanemasa T
FAU - Ninomiya, M
AU  - Ninomiya M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Spider Venoms)
RN  - 0 (omega-Agatoxin IVA)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain Edema/drug therapy/etiology
MH  - Calcium Channel Blockers/*pharmacology
MH  - Cerebral Infarction/*drug therapy/etiology
MH  - Consciousness
MH  - Ischemic Attack, Transient/complications/*drug therapy
MH  - Male
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/drug therapy
MH  - Spider Venoms/*pharmacology
MH  - omega-Agatoxin IVA
EDAT- 1998/01/24 00:00
MHDA- 1998/01/24 00:01
CRDT- 1998/01/24 00:00
PHST- 1998/01/24 00:00 [pubmed]
PHST- 1998/01/24 00:01 [medline]
PHST- 1998/01/24 00:00 [entrez]
AID - S0006-8993(97)00975-X [pii]
AID - 10.1016/s0006-8993(97)00975-x [doi]
PST - ppublish
SO  - Brain Res. 1997 Nov 21;776(1-2):140-5. doi: 10.1016/s0006-8993(97)00975-x.