PMID- 9441893
OWN - NLM
STAT- MEDLINE
DCOM- 19980310
LR  - 20131121
IS  - 0026-2862 (Print)
IS  - 0026-2862 (Linking)
VI  - 54
IP  - 3
DP  - 1997 Nov
TI  - Bradykinin and tumor necrosis factor-alpha alter albumin transport in vivo: a 
      comparative study.
PG  - 221-32
AB  - These studies indicate that tumor necrosis factor-alpha (TNF alpha) alters 
      albumin permeability and unlike bradykinin (BK) the increased albumin 
      permeability lasts for the duration of the application. Neither agonist requires 
      the presence of white blood cells or other blood-borne substances to produce this 
      inflammatory response. These experiments were completed in the in situ, 
      microcannulated, perfused venules of the mesentery in the anesthetized hamster. 
      Albumin transport was measured using intravital fluorescence microscopy, 
      TRITC-labeled albumin, and densitometric tracking. Further, by varying the 
      intravascular pressure, the hydraulic (Lp(1 sigma)) and diffusive permeability 
      (P0) coefficients of these microvessels were determined. Both BK and TNF alpha 
      produced an increase in albumin flux, which was dependent upon the dose and time 
      domains. This response was present when the agonists were given by either intra- 
      or extravascular presentation. Both hydraulic coupling and microvascular 
      permeability were increased by BK and TNF alpha. TNF alpha increased albumin 
      permeability rapidly and its effect lasted as long as TNF alpha was present, 
      whereas the increased albumin transport by BK was biphasic. The results implicate 
      a dynamic modification in the microvascular wall to these inflammatory agonists 
      and the mechanism(s) for transduction in the endothelium are quite different.
FAU - Saulpaw, C E
AU  - Saulpaw CE
AD  - Department of Physiology, James H. Quillen College of Medicine, East Tennessee 
      State University, Johnson City 37614-0576, USA.
FAU - Joyner, W L
AU  - Joyner WL
LA  - eng
GR  - 17902/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Microvasc Res
JT  - Microvascular research
JID - 0165035
RN  - 0 (Serum Albumin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Animals
MH  - Biological Transport/drug effects
MH  - Bradykinin/*pharmacology
MH  - Capillary Permeability/drug effects
MH  - Cricetinae
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Mesentery
MH  - Mesocricetus
MH  - Serum Albumin/*metabolism
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Venous Pressure/drug effects
EDAT- 1998/01/27 00:00
MHDA- 1998/01/27 00:01
CRDT- 1998/01/27 00:00
PHST- 1998/01/27 00:00 [pubmed]
PHST- 1998/01/27 00:01 [medline]
PHST- 1998/01/27 00:00 [entrez]
AID - S0026-2862(97)92041-0 [pii]
AID - 10.1006/mvre.1997.2041 [doi]
PST - ppublish
SO  - Microvasc Res. 1997 Nov;54(3):221-32. doi: 10.1006/mvre.1997.2041.