PMID- 9442824
OWN - NLM
STAT- MEDLINE
DCOM- 19980226
LR  - 20190716
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 117
IP  - 6
DP  - 1997 Nov
TI  - Development of 11 beta-hydroxysteroid dehydrogenase expression in the rat 
      cochlea.
PG  - 841-4
AB  - 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the transformation 
      of active glucocorticoid (GC) steroids to inactive 11-oxosteroids, as well as the 
      reverse reaction. 11 beta-HSD was previously demonstrated specifically in the 
      spiral ligament of the lateral cochlear wall where it was co-localized with 
      adrenal steroid receptors. These findings imply that 11 beta-HSD regulates 
      binding of corticoids to their inner ear receptors. The GC receptor expression 
      initially occurs around the critical maturation period of the cochlear duct. 11 
      beta-HSD, which is an integral part of the cochlear steroid receptor system, 
      could indirectly affect glucocorticoid-mediated induction processes. In this 
      study the expression of 11 beta-HSD was studied in the postnatal rat cochlea from 
      the 3rd to 30th postnatal day. Bouin's fixed, paraffin-embedded cochlear sections 
      were processed for immunocytochemical detection of 11 beta-HSD using polyclonal 
      antibodies against 11 beta-HSD. 11 beta-HSD expression appeared at the 12th 
      postnatal day at low levels in spiral ligament tissues. From the 15th postnatal 
      day, 11 beta-HSD expression was stronger and similar to that of the adult 
      cochlea. No additional inner ear tissue region expressed 11 beta-HSD enzyme 
      during the observed period. 11 beta-HSD expression coincides with the onset of 
      functional maturity of the rat cochlear duct. The expression of 11 beta-HSD is 
      preceded by the expression of GC receptors which appeared at the 7th postnatal 
      day in the rat cochlea. These results further suggest an integrative role of the 
      cochlear steroid receptor system in the homeostasis and functional maturation of 
      the cochlea.
FAU - ten Cate, W J
AU  - ten Cate WJ
AD  - Department of Otorhinolaryngology, University of Essen, Germany.
FAU - Zuo, J
AU  - Zuo J
FAU - Lautermann, J
AU  - Lautermann J
FAU - Altenhoff, P
AU  - Altenhoff P
FAU - Rarey, K E
AU  - Rarey KE
LA  - eng
GR  - DC00716/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Receptors, Glucocorticoid)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Animals
MH  - Animals, Newborn
MH  - Cochlea/*enzymology/growth & development
MH  - Corticosterone/metabolism
MH  - Hydroxysteroid Dehydrogenases/*biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Glucocorticoid/physiology
EDAT- 1998/01/27 00:00
MHDA- 1998/01/27 00:01
CRDT- 1998/01/27 00:00
PHST- 1998/01/27 00:00 [pubmed]
PHST- 1998/01/27 00:01 [medline]
PHST- 1998/01/27 00:00 [entrez]
AID - 10.3109/00016489709114211 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 1997 Nov;117(6):841-4. doi: 10.3109/00016489709114211.