PMID- 9442892
OWN - NLM
STAT- MEDLINE
DCOM- 19980218
LR  - 20061115
IS  - 0066-4197 (Print)
IS  - 0066-4197 (Linking)
VI  - 31
DP  - 1997
TI  - Host-pathogen interactions during entry and actin-based movement of Listeria 
      monocytogenes.
PG  - 113-38
AB  - Listeria monocytogenes is a pathogenic bacterium that induces its own uptake into 
      mammalian cells, and spreads from one cell to another by an actin-based motility 
      process. Entry into host cells involves the bacterial surface proteins InlA 
      (internalin) and InlB. The receptor for InlA is the cell adhesion molecule 
      E-cadherin. InlB-mediated entry requires activation of the host protein 
      phosphoinositide (PI) 3-kinase, probably in response to engagement of a receptor. 
      Actin-based movement of L. monocytogenes is mediated by the bacterial surface 
      protein ActA. The N-terminal region of this protein is necessary and sufficient 
      for polymerization of host cell actin. Other host proteins involved in bacterial 
      motility include profilin, Vasodilator-Stimulated Phosphoprotein (VASP), the 
      Arp2/Arp3 complex, and cofilin. Studies of entry and intracellular movement of L. 
      monocytogenes could lead to a better understanding of receptor-ligand signaling 
      and dynamics of actin polymerization in mammalian cells.
FAU - Ireton, K
AU  - Ireton K
AD  - Unite des Interactions Bacteries-Cellules, Institut Pasteur, Paris, France.
FAU - Cossart, P
AU  - Cossart P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Genet
JT  - Annual review of genetics
JID - 0117605
RN  - 0 (Actins)
RN  - 0 (Bacterial Proteins)
SB  - IM
MH  - Actins/*physiology
MH  - Animals
MH  - Bacterial Proteins/*physiology
MH  - Humans
MH  - Listeria monocytogenes/*physiology
MH  - Mammals
RF  - 136
EDAT- 1997/01/01 00:00
MHDA- 1998/01/27 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/01/27 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1146/annurev.genet.31.1.113 [doi]
PST - ppublish
SO  - Annu Rev Genet. 1997;31:113-38. doi: 10.1146/annurev.genet.31.1.113.