PMID- 9443037
OWN - NLM
STAT- MEDLINE
DCOM- 19980212
LR  - 20061115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 21
IP  - 1
DP  - 1998 Jan
TI  - Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 
      aberrations in pancreatic carcinomas: frequent loss of 19p13.3 and gain of 
      19q13.1-13.2.
PG  - 8-16
AB  - Cytogenetic investigation of nine pancreatic carcinomas revealed structural 
      rearrangements of chromosome 19 in eight cases, resulting in a high frequency of 
      19p losses and 19q gains. To characterize these imbalances further, we performed 
      fluorescence in situ hybridization (FISH) analysis with 12 mapped and evenly 
      distributed cosmids. The FISH study not only verified the cytogenetic findings 
      but also disclosed additional chromosome 19 aberrations not detected by 
      chromosome banding analysis. Seven carcinomas displayed 19p losses, always 
      including 19p13.3, either through partial- or whole-arm deletions. Six cases 
      showed gain of 19q, usually as one to two copies above the ploidy level. In one 
      case, a high level of amplification in 19q13.1 was seen. The commonly 
      overrepresented segment was 19q13.1-13.2. These results suggest that genes of 
      importance in the development of pancreatic carcinomas are located in 19p13.3 and 
      19q13.1-13.2.
FAU - Hoglund, M
AU  - Hoglund M
AD  - Department of Clinical Genetics, Lund University Hospital, Sweden.
FAU - Gorunova, L
AU  - Gorunova L
FAU - Andren-Sandberg, A
AU  - Andren-Sandberg A
FAU - Dawiskiba, S
AU  - Dawiskiba S
FAU - Mitelman, F
AU  - Mitelman F
FAU - Johansson, B
AU  - Johansson B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Aged
MH  - Carcinoma/*genetics
MH  - Cytogenetics
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Loss of Heterozygosity/*genetics
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*genetics
MH  - *Translocation, Genetic
EDAT- 1998/01/27 05:24
MHDA- 2000/06/20 09:00
CRDT- 1998/01/27 05:24
PHST- 1998/01/27 05:24 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/01/27 05:24 [entrez]
AID - 10.1002/(SICI)1098-2264(199801)21:1<8::AID-GCC3>3.0.CO;2-5 [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1998 Jan;21(1):8-16.