PMID- 9443043 OWN - NLM STAT- MEDLINE DCOM- 19980212 LR - 20060406 IS - 1045-2257 (Print) IS - 1045-2257 (Linking) VI - 21 IP - 1 DP - 1998 Jan TI - Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder. PG - 70-3 AB - Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11-12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement. FAU - Smedley, D AU - Smedley D AD - Institute of Cancer Research, Sutton, Surrey, United Kingdom. FAU - Somers, G AU - Somers G FAU - Venter, D AU - Venter D FAU - Chow, C W AU - Chow CW FAU - Cooper, C AU - Cooper C FAU - Shipley, J AU - Shipley J LA - eng PT - Journal Article PL - United States TA - Genes Chromosomes Cancer JT - Genes, chromosomes & cancer JID - 9007329 SB - IM MH - Chromosomes, Artificial, Yeast MH - Chromosomes, Human, Pair 13/*genetics MH - Chromosomes, Human, Pair 8/*genetics MH - Humans MH - Karyotyping MH - Metaphase MH - Myeloproliferative Disorders/*genetics MH - Nucleic Acid Hybridization MH - *Translocation, Genetic EDAT- 1998/01/27 05:24 MHDA- 2000/06/20 09:00 CRDT- 1998/01/27 05:24 PHST- 1998/01/27 05:24 [pubmed] PHST- 2000/06/20 09:00 [medline] PHST- 1998/01/27 05:24 [entrez] AID - 10.1002/(SICI)1098-2264(199801)21:1<70::AID-GCC9>3.0.CO;2-5 [pii] PST - ppublish SO - Genes Chromosomes Cancer. 1998 Jan;21(1):70-3.