PMID- 9443558
OWN - NLM
STAT- MEDLINE
DCOM- 19980309
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 59
IP  - 1
DP  - 1998 Jan
TI  - CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of 
      cocaine and MDMA conditioned place preferences.
PG  - 215-20
AB  - Cocaine and methylenedioxymethamphetamine (MDMA), two drugs self-administered by 
      humans and laboratory animals, have previously been shown to produce conditioned 
      place preferences (CPPs) among rats, an index of drug-reward relevant events. 
      Both of these agents increase functional levels of dopamine that may be critical 
      to their rewarding properties. Here, the effects of doses of CGS 10746B, an agent 
      reported to attenuate the release of dopamine without occupying dopamine 
      receptors, are assessed on cocaine and MDMA's ability to produce a CPP. CGS 
      10746B dose dependently blocked the establishment of a MDMA CPP. A 30 mg/kg dose 
      of CGS 10746B, which completely blocked the MDMA CPP, also blocked the 
      establishment of a cocaine CPP. Release of dopamine appears critical to the 
      ability of these agents to establish a CPP.
FAU - Bilsky, E J
AU  - Bilsky EJ
AD  - Department of Biological Sciences, University of Northern Colorado, Greeley 
      80639, USA. ejbilsk@bentley.univnorthco.edu
FAU - Montegut, M J
AU  - Montegut MJ
FAU - Nichols, M L
AU  - Nichols ML
FAU - Reid, L D
AU  - Reid LD
LA  - eng
GR  - DA 04440/DA/NIDA NIH HHS/United States
GR  - DA 08937/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Dopamine Agents)
RN  - 0 (Thiazepines)
RN  - 81382-52-7 (CGS 10746B)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Choice Behavior/*drug effects
MH  - Cocaine/*antagonists & inhibitors
MH  - Conditioning, Operant/*drug effects
MH  - Cues
MH  - Dopamine/metabolism
MH  - Dopamine Agents/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*antagonists & inhibitors
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thiazepines/*pharmacology
EDAT- 1998/01/27 00:00
MHDA- 1998/01/27 00:01
CRDT- 1998/01/27 00:00
PHST- 1998/01/27 00:00 [pubmed]
PHST- 1998/01/27 00:01 [medline]
PHST- 1998/01/27 00:00 [entrez]
AID - S0091-3057(97)00424-3 [pii]
AID - 10.1016/s0091-3057(97)00424-3 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1998 Jan;59(1):215-20. doi: 
      10.1016/s0091-3057(97)00424-3.