PMID- 9443808
OWN - NLM
STAT- MEDLINE
DCOM- 19980217
LR  - 20190512
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 122
IP  - 5
DP  - 1997 Nov
TI  - Mouse Mef2b gene: unique member of MEF2 gene family.
PG  - 939-46
AB  - The myocyte enhancer factor 2 (MEF2) gene family, which belongs to the MADS 
      [MCM1, agamous, deficiens, serum response factor (SRF)] superfamily, is thought 
      to play an important role in differentiation of myocytes, including 
      cardiomyocytes. To better understand the mouse Mef2 gene family, the mouse Mef2b 
      gene, which was found to be expressed in undifferentiated embryonal cells, was 
      characterized. The Mef2b gene was found to be more than 30 kb in length, 
      consisting of 11 exons. Eight exons correspond to coding regions and the 
      remaining 3 exons for the 5' part are alternatively used. Two internal exons are 
      subject to alternative splicing, resulting in production of four subtypes of 
      mouse MEF2B peptides. Fluorescence in situ hybridization (FISH) and 
      inter-specific backcross analysis identified the Mef2b gene locus. Mef2b gene was 
      expressed in heart or skeletal muscle of early mouse embryo, but not in those of 
      adult mouse. Functionally, mouse MEF2B did not exhibit DNA binding with the MEF2 
      consensus element in vitro, but did cause transcriptional activation of the MEF2 
      element, although it was less effective than human MEF2B. Based on these results, 
      mouse MEF2B seems to have a unique character, distinct from other MEF2 family 
      members.
FAU - Morisaki, T
AU  - Morisaki T
AD  - Department of Bioscience, National Cardiovascular Center Research Institute, 
      Suita, Osaka. morisaki@ri.ncvc.go.jp
FAU - Sermsuvitayawong, K
AU  - Sermsuvitayawong K
FAU - Byun, S H
AU  - Byun SH
FAU - Matsuda, Y
AU  - Matsuda Y
FAU - Hidaka, K
AU  - Hidaka K
FAU - Morisaki, H
AU  - Morisaki H
FAU - Mukai, T
AU  - Mukai T
LA  - eng
SI  - GENBANK/D87828
SI  - GENBANK/D87829
SI  - GENBANK/D87830
SI  - GENBANK/D87831
SI  - GENBANK/D87832
SI  - GENBANK/D87833
SI  - GENBANK/D87834
SI  - GENBANK/D87835
SI  - GENBANK/D87836
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MEF2 Transcription Factors)
RN  - 0 (Mef2b protein, mouse)
RN  - 0 (Myogenic Regulatory Factors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/biosynthesis/*genetics/*isolation & purification/metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - In Situ Hybridization, Fluorescence
MH  - MEF2 Transcription Factors
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Muridae
MH  - Myogenic Regulatory Factors
MH  - Organ Specificity/genetics
MH  - Teratocarcinoma
MH  - Transcription Factors/biosynthesis/*genetics/*isolation & purification/metabolism
MH  - Tumor Cells, Cultured
EDAT- 1998/01/27 00:00
MHDA- 1998/01/27 00:01
CRDT- 1998/01/27 00:00
PHST- 1998/01/27 00:00 [pubmed]
PHST- 1998/01/27 00:01 [medline]
PHST- 1998/01/27 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a021855 [doi]
PST - ppublish
SO  - J Biochem. 1997 Nov;122(5):939-46. doi: 10.1093/oxfordjournals.jbchem.a021855.