PMID- 9443814
OWN - NLM
STAT- MEDLINE
DCOM- 19980217
LR  - 20190512
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 122
IP  - 5
DP  - 1997 Nov
TI  - Isolation and characterization of the plasma hyaluronan-binding protein (PHBP) 
      gene (HABP2).
PG  - 983-90
AB  - PHBP is a novel human plasma hyaluronan-binding protein that shows significant 
      homology in amino acid sequence to hepatocyte growth factor activator. Two 
      overlapping clones that encode the human plasma hyaluronan-binding protein (PHBP) 
      gene (HABP2) were isolated and characterized. The PHBP gene spans 35 kb and is 
      composed of 13 exons from 37 to 1,394 bp in size with consensus splice sites. The 
      gene's regulatory sequences contain putative promoter elements, but no typical 
      TATA box. Some exons of this gene showed significant similarities to those of 
      coagulation factor XII, tissue-type plasminogen activator, and urokinase genes in 
      nucleotide length and in intron phasing. We also report the chromosome mapping of 
      this gene by fluorescence in situ hybridization (FISH) using a genomic DNA 
      fragment as a probe. The PHBP gene (HABP2) was located on chromosome 10q25-q26.
FAU - Sumiya, J
AU  - Sumiya J
AD  - Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa 
      University, Tokyo.
FAU - Asakawa, S
AU  - Asakawa S
FAU - Tobe, T
AU  - Tobe T
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Saguchi, K
AU  - Saguchi K
FAU - Choi-Miura, N H
AU  - Choi-Miura NH
FAU - Shimizu, Y
AU  - Shimizu Y
FAU - Minoshima, S
AU  - Minoshima S
FAU - Shimizu, N
AU  - Shimizu N
FAU - Tomita, M
AU  - Tomita M
LA  - eng
SI  - GENBANK/D49742
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (RNA, Messenger)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - EC 3.4.21.- (HABP2 protein, human)
RN  - EC 3.4.21.- (HGF activator)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Base Sequence
MH  - Chromosomes, Human, Pair 10/genetics
MH  - Cloning, Molecular
MH  - Exons
MH  - Humans
MH  - Hyaluronic Acid/*metabolism
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger/analysis
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Nucleic Acid
MH  - Serine Endopeptidases/blood/chemistry/*genetics/isolation & purification
MH  - Transcription, Genetic
EDAT- 1998/01/27 00:00
MHDA- 1998/01/27 00:01
CRDT- 1998/01/27 00:00
PHST- 1998/01/27 00:00 [pubmed]
PHST- 1998/01/27 00:01 [medline]
PHST- 1998/01/27 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a021861 [doi]
PST - ppublish
SO  - J Biochem. 1997 Nov;122(5):983-90. doi: 10.1093/oxfordjournals.jbchem.a021861.