PMID- 9444599
OWN - NLM
STAT- MEDLINE
DCOM- 19980227
LR  - 20081121
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 68
IP  - 12
DP  - 1997 Dec
TI  - Host defensive, immunological, and microbiological observations of an early-onset 
      periodontitis patient with virus-associated hemophagocytic syndrome.
PG  - 1223-30
AB  - Virus-associated hemophagocytic syndrome (VAHS) is a disorder characterized by 
      benign generalized histiocytic proliferation and marked hemophagocytosis 
      associated with systemic viral infection. An immunodeficiency which includes an 
      extremely decreased leukocyte and platelet count together with abnormalities in 
      the CD4/CD8 ratio are the most common features of VAHS. Here we report an 
      early-onset periodontitis (EOP) patient with VAHS from the standpoint of 
      host-parasite interaction to understand the effect of this systemic disorder 
      which might possibly influence susceptibility to periodontal disease. The patient 
      is a 16-year-old Japanese male clinically diagnosed as having generalized EOP 
      with slight gingival inflammation and moderate bone loss. This patient manifested 
      VAHS at 3 years of age, and then had an unusual 4 recurrences (at 5, 7, 11, and 
      14 years old). Laboratory tests conducted include: 1) complete blood analyses: 2) 
      peripheral neutrophil functions (chemotaxis, phagocytosis, superoxide production, 
      and adherence); 3) peripheral lymphocyte subpopulations and functions, T-cell 
      proliferative activity and productivity of cytokines (interleukin-2 [IL-2], 
      interferon gamma [IFN-gamma], and tumor necrosis factor alpha [TNF-alpha]); 4) 
      serum cytokine levels (IL-1 beta, IL-2, soluble IL-2 receptor [sIL-2R], IL-4, 
      IL-6, IFN-gamma, and TNF-alpha; 5) serum immunoglobulin G (IgG) antibody titers 
      against periodontopathic bacteria; 6) serological human leukocyte antigen (HLA) 
      typing; and 7) determination of bacterial flora of the periodontal pockets. The 
      results indicated that the patient's neutrophil chemotaxis and random migration 
      were below the normal range. In lymphocyte examinations, T-cell proliferative 
      activity, IL-2, and IFN-gamma productivity were elevated. Serum IFN-gamma level 
      was also significantly higher than normal range. No specific periodontopathic 
      bacteria were predominant in the periodontal pockets, however, the serum IgG 
      titer against Porphyromonas gingivalis was elevated throughout the examination 
      period. It is suggested that VAHS might be a possible risk factor for periodontal 
      disease, and hence may serve as a model in understanding the role of host defense 
      mechanisms in the establishment of inflammatory periodontal disease.
FAU - Kono, T
AU  - Kono T
AD  - Department of Periodontology and Endodontology, Okayama University Dental School, 
      Japan.
FAU - Takigawa, M
AU  - Takigawa M
FAU - Nishimura, F
AU  - Nishimura F
FAU - Takashiba, S
AU  - Takashiba S
FAU - Nakagawa, M
AU  - Nakagawa M
FAU - Maeda, H
AU  - Maeda H
FAU - Arai, H
AU  - Arai H
FAU - Nagai, A
AU  - Nagai A
FAU - Kurihara, H
AU  - Kurihara H
FAU - Murayama, Y
AU  - Murayama Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Aggressive Periodontitis/*immunology/microbiology/virology
MH  - Alveolar Bone Loss/immunology/microbiology/virology
MH  - Antibodies, Bacterial/blood
MH  - Bacteria/isolation & purification
MH  - CD4-CD8 Ratio
MH  - Cell Division
MH  - Cytomegalovirus Infections
MH  - Disease Susceptibility/immunology
MH  - Follow-Up Studies
MH  - Gingivitis/immunology/microbiology/virology
MH  - HLA Antigens/analysis
MH  - Herpesviridae Infections
MH  - Herpesvirus 4, Human
MH  - Histiocytosis, Non-Langerhans-Cell/*immunology/microbiology/virology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Interferon-gamma/biosynthesis/blood
MH  - Interleukin-1/blood
MH  - Interleukin-2/biosynthesis/blood
MH  - Interleukin-4/blood
MH  - Interleukin-6/blood
MH  - Leukocyte Count
MH  - Lymphocyte Subsets/physiology
MH  - Male
MH  - Neutrophils/physiology
MH  - Periodontal Pocket/microbiology
MH  - Platelet Count
MH  - Receptors, Interleukin-2/blood
MH  - Recurrence
MH  - T-Lymphocytes/physiology
MH  - Tumor Necrosis Factor-alpha/analysis/biosynthesis
MH  - Tumor Virus Infections
EDAT- 1998/01/28 00:00
MHDA- 1998/01/28 00:01
CRDT- 1998/01/28 00:00
PHST- 1998/01/28 00:00 [pubmed]
PHST- 1998/01/28 00:01 [medline]
PHST- 1998/01/28 00:00 [entrez]
AID - 10.1902/jop.1997.68.12.1223 [doi]
PST - ppublish
SO  - J Periodontol. 1997 Dec;68(12):1223-30. doi: 10.1902/jop.1997.68.12.1223.